Results 231 to 240 of about 3,492,596 (401)

An update on the development of novel antifungal agents for eumycetoma. [PDF]

Front Pharmacol, 2023
Chandler DJ, Bonifaz A, van de Sande WWJ.   +2 more
europepmc   +1 more source

Boron‐Based Functionalities Enhance the Potency of 2,5‐Dimethylfuran‐Based IDO1 Inhibitors

ChemBioChem, EarlyView.
Indoleamine‐2,3‐dioxygenase‐1 (IDO1), a key immunoregulatory enzyme, is inhibited by novel boron derivatives (closo‐1,2‐ and 1,7‐carborane, boronic acids and esters, and benzoxaboroles) of 2,5‐dimethylfuran, each displaying low μM affinity for the human recombinant enzyme.
Thomas J. C. Carraro, Samrat Dasgupta, Jacqueline Ku, Shane R. Thomas, Louis M. Rendina   +4 more
wiley   +1 more source

The role of the Mediator complex in fungal pathogenesis and response to antifungal agents. [PDF]

Essays Biochem, 2023
O'Connor-Moneley J, Alaalm L, Moran GP, Sullivan DJ.   +3 more
europepmc   +1 more source

Biosynthesis of the Fungal Cyclic Lipodepsipeptide Pleosporacin, a New Selective Inhibitor of the Phytopathogen Botrytis cinerea

ChemBioChem, EarlyView.
Bioactivity‐guided isolation led to the discovery of a potent and selective inhibitor of the phytopathogen Botrytis cinerea, pleosporacin (1), from mycelia extracts of the fungal strain Pleosporales sp. IBWF 020‐21. The biosynthesis of the nonribosomal cyclic lipodepsipeptide 1 was elucidated via heterologous reconstitution in Aspergillus oryzae ...
Carsten Wieder, Rainer Wiechert, Alexander Yemelin, Louis Pergaud Sandjo, Eckhard Thines, Till Opatz, Anja Schüffler   +6 more
wiley   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Antifungal Agents' Trends of Utilization, Spending, and Prices in the US Medicaid Programs: 2009-2023. [PDF]

Antibiotics (Basel)
Alsuhibani AA, Alobaid NA, Alahmadi MH, Alqannas JS, Alfreaj WS, Albadrani RF, Alamer KA, Almogbel YS, Alhomaidan A, Guo JJ.   +9 more
europepmc   +1 more source

A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity.

Chemistry – A European Journal, Accepted Article.
Ketol‐acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino acid biosynthesis in plants and microorganisms, and its absence in animals. The lack of success in developing KARI inhibitors as biocides may be because the inhibitors assessed to date compete directly ...
Luke William Guddat, Xin Lin, Julia L. Kurz, Yong-Hong Li, Shun Jie Wun, Thierry Lonhienne, Ross P. McGeary, Nicholas P. West, Gerhard Schenk, Jian-Guo Wang   +9 more
wiley   +1 more source

In vitro activity of systemic antifungal agents against Malassezia furfur

, 1987
Mario J. Marcon, Diane E. Durrell, Dwight A. Powell, William J. Buesching   +3 more
openalex   +1 more source

Exploring the Potential of s-Triazine Derivatives as Novel Antifungal Agents: A Review. [PDF]

Pharmaceuticals (Basel)
Liao H, Liu M, Wang M, Zhang D, Hao Y, Xie F.   +5 more
europepmc   +1 more source

Editorial: Use of chemosensitization to augment efficacy of antifungal agents, Volume II. [PDF]

Front Fungal Biol, 2023
Kim JH, Sebolai OM, Dzhavakhiya V.
europepmc   +1 more source