Results 251 to 260 of about 219,275 (300)
Some of the next articles are maybe not open access.
Hospital Medicine, 2004
With the relentless increase in invasive fungal infections, particularly in critically ill and immunocompromised patients, it is good to know that there are new additions to the antifungal armamentarium. These include not only new formulations of existing drugs and the development of new triazole agents, but also the introduction of a new class of ...
Anjali, Shetty, Rosemary A, Barnes
openaire +4 more sources
With the relentless increase in invasive fungal infections, particularly in critically ill and immunocompromised patients, it is good to know that there are new additions to the antifungal armamentarium. These include not only new formulations of existing drugs and the development of new triazole agents, but also the introduction of a new class of ...
Anjali, Shetty, Rosemary A, Barnes
openaire +4 more sources
Science, 1961
From the soil of the San Joaquin Valley a fungus has been isolated, an extract of which inhibits the growth of Coccidioides immitis on Sabouraud's medium. An acute toxicity study in mice indicates a certain tolerance of the extract. Tentative identification indicates that the fungus is a penicillium.
M C, EGEBERG, A F, ELCONIN, R O, EGEBERG
openaire +2 more sources
From the soil of the San Joaquin Valley a fungus has been isolated, an extract of which inhibits the growth of Coccidioides immitis on Sabouraud's medium. An acute toxicity study in mice indicates a certain tolerance of the extract. Tentative identification indicates that the fungus is a penicillium.
M C, EGEBERG, A F, ELCONIN, R O, EGEBERG
openaire +2 more sources
Seminars in Respiratory Infections, 2002
Treatment of fungal infections is an area of increasing concern. This is because of the complexity of underlying illness in affected patients as well as the limited number of antifungal agents available for use. Current strategies focus on prevention of these infections in patients at high risk; however, this has the potential to lead to the emergence ...
Irene, Lu +2 more
openaire +4 more sources
Treatment of fungal infections is an area of increasing concern. This is because of the complexity of underlying illness in affected patients as well as the limited number of antifungal agents available for use. Current strategies focus on prevention of these infections in patients at high risk; however, this has the potential to lead to the emergence ...
Irene, Lu +2 more
openaire +4 more sources
Antifungal agents, WO2009025733
Expert Opinion on Therapeutic Patents, 2009The incidence and prevalence of serious mycoses continues to be a public health problem. These infections are an important cause of morbidity and mortality, especially in immunocompromised patients. The present patent deals with isolation and characterization of a 'pure' mixture of two novel isoxazolidinone-containing natural products from two new ...
Pore Vandana, Sudhir +2 more
openaire +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2003
Compounds based on sordaricin were prepared via organometallic addition onto a fully protected sordaricin aldehyde. The fungal growth inhibition profiles for these compounds were established and the results are presented here. The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement ...
Claude A, Quesnelle +11 more
openaire +2 more sources
Compounds based on sordaricin were prepared via organometallic addition onto a fully protected sordaricin aldehyde. The fungal growth inhibition profiles for these compounds were established and the results are presented here. The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement ...
Claude A, Quesnelle +11 more
openaire +2 more sources
The Indian Journal of Pediatrics, 2004
Invasive fungal infections have evolved into significant causes of morbidity and mortality in premature infants, immunocompromised children, and patients receiving immunosuppressive agents. Since the discovery in 1955, amphotericin B has been the cornerstone of antifungal treatment.
Walid, Abuhammour, Eyassu, Habte-Gaber
openaire +2 more sources
Invasive fungal infections have evolved into significant causes of morbidity and mortality in premature infants, immunocompromised children, and patients receiving immunosuppressive agents. Since the discovery in 1955, amphotericin B has been the cornerstone of antifungal treatment.
Walid, Abuhammour, Eyassu, Habte-Gaber
openaire +2 more sources
Dermatologic Clinics, 2003
Currently, use of standard antifungal therapies can be limited because of toxicity, low efficacy rates, and drug resistance. New formulations are being prepared to improve absorption and efficacy of some of these standard therapies. Various new antifungals have demonstrated therapeutic potential.
Aditya K, Gupta, Elizabeth, Tomas
openaire +2 more sources
Currently, use of standard antifungal therapies can be limited because of toxicity, low efficacy rates, and drug resistance. New formulations are being prepared to improve absorption and efficacy of some of these standard therapies. Various new antifungals have demonstrated therapeutic potential.
Aditya K, Gupta, Elizabeth, Tomas
openaire +2 more sources
Clinical Infectious Diseases, 1992
The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
openaire +2 more sources
The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
openaire +2 more sources
Current Opinion in Pediatrics, 2013
In recent years there has been an evolution of a better understanding of the pharmacology and clinical indications of existing antifungal agents and also the development of new broad-spectrum triazoles and a newer class of antifungal agents, the echinocandins.
Beatriz, Larru, Theoklis E, Zaoutis
openaire +2 more sources
In recent years there has been an evolution of a better understanding of the pharmacology and clinical indications of existing antifungal agents and also the development of new broad-spectrum triazoles and a newer class of antifungal agents, the echinocandins.
Beatriz, Larru, Theoklis E, Zaoutis
openaire +2 more sources
The Indian Journal of Pediatrics, 2001
Anti-fungal agents are classified under two major headings, systematic and topical agents. Only systematic anti-fungal agents will be discussed in this chapter. Since the discovery in 1955, amphotericin B has been the cornerstone of anti-fungal treatment. It is active against most species of fungi.
W, Abuhammour, E, Habte-Gabr
openaire +2 more sources
Anti-fungal agents are classified under two major headings, systematic and topical agents. Only systematic anti-fungal agents will be discussed in this chapter. Since the discovery in 1955, amphotericin B has been the cornerstone of anti-fungal treatment. It is active against most species of fungi.
W, Abuhammour, E, Habte-Gabr
openaire +2 more sources