Results 111 to 120 of about 197,518 (344)

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Minimal inhibitory concentration distributions and epidemiological cutoff values of five antifungal agents against Sporothrix brasiliensis

Memorias do Instituto Oswaldo Cruz
BACKGROUND Sporothrix brasiliensis is the most virulent sporotrichosis agent. This species usually responds to antifungal drugs, but therapeutic failure can occur in some patients.
Rodrigo Almeida-Paes, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Ana Caroline Sá Machado, Manoel Marques Evangelista Oliveira, Sandro Antonio Pereira, Maria Clara Gutierrez-Galhardo, Rosely Maria Zancopé-Oliveira   +7 more
doaj   +1 more source

Silk Fibroin Hydrogel-Assisted Controlled Release of Antifungal Drug Ketoconazole

, 2023
Tomal Chandro Roy, Rezaul Haque Ansary, Protyasha Biswas, Md Ali Haider   +3 more
openalex   +2 more sources

The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]

, 2017
N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
Aimanianda, Aimanianda, Al-Fattani, Albrecht, Albuquerque, Alvarez, Arroyo, Babady, Baker, Beauvais, Beauvais, Beauvais, Becker, Bonhomme, Bowen, Brown, Bruno, Bulmer, Butler, Cabib, Cabib, Cabib, Cabib, Casadevall, Casadevall, Cassone, Cassone, Castillo, Chaffin, Cheetham, Cho, Coronado, Couto, Crowe, Cushion, Cutler, Cutler, Da Silva, Dadachova, Dadachova, Dague, Dan, De Las Peñas, Del Poeta, DeMarini, Dennehy, Doering, Domer, Douglas, Douglas, Duro, Eisenhaber, Eisenman, Ene, Erwig, Fairlamb, Fernandes, Firon, Fleet, Fontaine, Frieman, Fu, Gagnon-Arsenault, García, García, Gilbert, Glasgow, Gravelat, Gresnigt, Groot, Groot, Groot, Groot, Hall, Hancock, Henry, Herrero, Hiller, Hilpert, Hohl, Hoyer, Hurtado-Guerrero, Ibrahim, Iorio, Irazoqui, Ito, Johnson, Kanetsuna, Karababa, Kaur, Kim, Klis, Klis, Klutts, Kozubowski, Kozubowski, Lamaris, Langfelder, Larsen, Latge, Latgé, Lee, Lee, Lee, Lenardon, Lenardon, Lesage, Levin, Li, Li, Li, Lipschutz, Lombard, Ma, Ma, MacCallum, Machesky, Macho, Martinez, Marty, Martín-Cuadrado, McFadden, Mentlak, Money, Money, Morelle, Morozov, Mouyna, Mouyna, Moyrand, Munro, Munro, Munro, Müller, Netea, Nett, Nobile, Norice, Nosanchuk, Nosanchuk, Odds, Oliveira-Garcia, Oliveira-Garcia, Ostrosky-Zeichner, Paolo, Paris, Park, Perlin, Piotrowski, Pitarch, Popolo, Pérez, Rachini, Rajendran, Rappleye, Rappleye, Rauceo, Reese, Reese, Reese, Reid, Reinoso-Martín, Rispail, Román, Roncero, Rowbottom, Sandini, Schorr, Schuster, Seidl, Selvaggini, Sendid, Shahinian, Sheppard, Sohn, Sorgo, Spellberg, Staab, Steinbach, Steinbach, Steinberg, Steinberg, Stynen, Sudbery, Sundstrom, Sánchez-Vallet, Thompson, Torosantucci, Treitschke, Tsai, Urban, Valdivia, Vargas-Muñiz, Veerdonk, Virag, Wagener, Walker, Walker, Walker, Walton, Weber, Wessels, Wessels, Wheeler, Wheeler, Wiederhold, Wozniak, Wösten, Xin, xSchuster, Yin, Yoneda, Zaragoza, Zarnowski, Zipfel, Zupancic   +215 more
core   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Combination of Farnesol with Common Antifungal Drugs: Inhibitory Effect against Clinical Isolates of <em>Candida</em> Species

, 2023
Fatemeh Nikoomanesh, Mahsa Falahati, André Luis Souza dos Santos, Célia F. Rodrigues, Shahla Roudbar Mohammadi, Mitra Rafiee, Lucia Černáková, Maryam Roudbary   +7 more
openalex   +2 more sources

Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB. [PDF]

, 2016
Repurposing has gained momentum globally and become an alternative avenue for drug discovery because of its better success rate, and reduced cost, time and issues related to safety than the conventional drug discovery process.
Brindha, Sridharan, Gnanadoss, John Joel, Sundaramurthi, Jagadish Chandrabose, Velmurugan, Devadasan, Vincent, Savariar   +4 more
core   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles

Brazilian Journal of Infectious Diseases, 2013
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored.
Ravikumar Bapurao Shinde, Jayant Shankar Raut, Nitin Mahendra Chauhan, Sankunny Mohan Karuppayil   +3 more
doaj   +1 more source