Results 151 to 160 of about 197,518 (344)

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Antifungal drug therapy

Revista do Instituto de Medicina Tropical de São Paulo, 1991
Paul H. JACOBS, Lexie NALL
doaj   +1 more source

Photocatalytically Activated Cu‐N1S3 Single‐Atom Nanozyme: Enhancing Enzyme Activities and Antibacterial Synergy for Highly Efficient Fruit Preservation

Advanced Science, EarlyView.
This study presents S‐coordinated Cu single‐atom nanozymes (Cu/CNS) fabricated via mild photocatalytic self‐assembly strategy. The nanozyme exhibits exceptional multi‐enzyme activity and near‐perfect antimicrobial efficacy. Incorporated into chitosan‐gelatin film, it enables pH‐responsive, broad‐spectrum fruit preservation, more than doubling the shelf‐
Chuanlong Men, Chenchen Wu, Lei Wang, Shengjie Gao, Yu Mao, Wei Liu, Changhong Liu, Lei Zheng   +7 more
wiley   +1 more source

Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype [PDF]

, 2016
Lourimar Viana Nascimento Franco de Sousa, Vera Lúcia dos Santos, Andrea de Souza Monteiro, Marcus Vinícius Dias-Souza, Sirlei Garcia Marques, Elaine Speziali de Faria, Elaine Alves de Oliveira Assunção, Simone Gonçalves dos Santos, Juan Moises Zonis, Daniel Alvarenga, Rodrigo Assunção Holanda, Jaqueline Gontijo de Sousa, Kênia Valéria dos Santos, Maria Aparecida de Resende   +13 more
openalex   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals sphingolipids are involved in the potential mechanism of action of miltefosine

, 2021
Gustavo H. Goldman
openalex   +1 more source

Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis [PDF]

, 2023
Liu-liu Sun, Hao Li, Tianhua Yan, Yongbing Cao, Yuanying Jiang, Feng Yang   +5 more
openalex   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Describing Antifungal Drug-Sterol Interactions Inside the Membrane: The Role of Dynamics [PDF]

, 2021
Kevin J. Cheng, Ashley M. De Lio, Agnieszka Lewandowska, Corinne P. Soutar, Martin D. Burke, Chad M. Rienstra, Taras V. Pogorelov   +6 more
openalex   +1 more source