Results 171 to 180 of about 3,938,965 (348)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Improved Sixty-Day Mortality in Candidemia with Antifungal Treatment Within 72 Hours of Fever Onset: A Single-Center Retrospective Study in Rural Japan

Infectious Disease Reports
Introduction: Prognostic factor investigations for candidemia have been conducted in large-scale facilities, leading to significant evidence, including early administration of echinocandin antifungal agents and removal of central venous catheters (CVCs).
Koji Hayashi, Chizuru Hashimoto, Kohei Ueda, Yuka Nakaya, Asuka Suzuki, Maho Hayashi, Mamiko Sato, Yasutaka Kobayashi   +7 more
doaj   +1 more source

Analysis of Inhibitory Effects of Antifungal Drugs on Trichophyton.

, 1963
Kenji Yasumoto, Yoshitoshi SHIMOTSUURA, Takeo Nakama   +2 more
openalex   +2 more sources

Self-medication with vaginal antifungal drugs: physicians' experiences and women's utilization patterns [PDF]

, 2000
Sinikka Sihvo, Riitta Ahonen, H. Mikander, Elina Hemminki   +3 more
openalex   +1 more source

SIP‐SRS Imaging of Cell Wall Synthesis Identifies a Synergy between Micafungin and Amphotericin B

Advanced Science, EarlyView.
We employed glucose‐d7–based stable isotope probe‐assisted SRS microscopy (SIP‐SRS) C–D imaging to visualize fungal cell wall synthesis and remodeling under antifungal treatment. Amphotericin B (AmB) induced notable daughter cell wall thickening, prompting a combinational therapy with AmB and micafungin.
Meng Zhang, Yuewei Zhan, Haonan Lin, Jiyang Chen, Mohamed N. Seleem, Michael Mansour, Ji‐Xin Cheng   +6 more
wiley   +1 more source

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species

Pathogens
Pathogenic fungi that exhibit the ability to alternate between hyphal and yeast morphology in response to environmental stimuli are considered dimorphic. Under saprobic conditions, some fungi exist as filamentous hyphae, producing conidia.
Uriel Ramírez-Sotelo, Manuela Gómez-Gaviria, Héctor M. Mora-Montes   +2 more
doaj   +1 more source

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs

, 1979
Dante Borelli, José L. Bran, J. Fuentes, R. Legendre, Eduardo A Leiderman, H. B. Levine, Angela Restrepo-M., David A. Stevens   +7 more
openalex   +1 more source

In vitro susceptibility of Cryptococcus neoformans isolates to five antifungal drugs using a colorimetric system and the reference microbroth method [PDF]

, 2000
Olga López-Jodra
openalex   +1 more source