Results 281 to 290 of about 3,938,965 (348)

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Establishment, Characterization, and Cryopreservation of Feather Follicle Fibroblast Lines From Hyacinth Macaw (Anodorhynchus hyacinthinus)

Cell Biology International, EarlyView.
ABSTRACT Cryopreservation, biobanking, and in vitro propagation of cells from endangered species represent key strategies for advancing biodiversity conservation. The Hyacinth Macaw (Anodorhynchus hyacinthinus), a flagship avian species of the Brazilian Pantanal, is among the critically vulnerable taxa that stand to benefit significantly from such ...
Iara Pastor Martins Nogueira, Rachel Castro Teixeira‐Santos, Gustavo Caldeira Cotta, Wanderson Valente, John Lennon Paiva de Coimbra, Heloísa Athaydes Seabra Ferreira, Pedro Pires Goulart Guimarães, Anderson Kenedy Santos, Fernanda Mussi Fontoura, Kefany Rodrigues de Andrade Ramalho, Neiva Maria Robaldo Guedes, Samyra Maria dos Santos Nassif Lacerda   +11 more
wiley   +1 more source

Sustainable One‐Pot Synthesis of N‐Substituted Pyrroles Using a Multifunctional Cobalt‐Based Catalyst

ChemCatChem, EarlyView.
The one‐pot synthesis of N‐substituted pyrroles from nitrobenzene and 2,5‐hexanodione is first ever reported with >99% conversion and >99% chemoselectivity, in a green solvent, using a non‐noble metal‐based catalyst and hydrogen as a reductant under mild reaction conditions simultaneously.
Jose Luis del Río‐Rodríguez, Arisbeth Tiscareño‐Ferrer, Silvia Gutiérrez‐Tarriño, Pascual Oña‐Burgos   +3 more
wiley   +1 more source

CuH‐Catalyzed Asymmetric Desymmetrization of Cyclobutenes via Stereodivergent Hydroamination

ChemistryEurope, EarlyView.
The CuH‐catalyzed stereodivergent hydroamination through asymmetric desymmetrization of cyclobutenes has been achieved, yielding a range of trisubstituted aminocyclobutanes with excellent results. A series of subsequent transformations, including the first asymmetric synthesis of two pharmaceutically active molecules, have been realized, and density ...
Xiang Lei, Peng Luo, Shouang Lan, Wennan Dong, Chao Xu, Jinggong Liu, Shuang Yang, Qi Zhang, Xinqiang Fang   +8 more
wiley   +1 more source

Bioinspired Light‐Driven Organic Rotary Molecular Systems

ChemistryEurope, EarlyView.
This review explores the evolution of bioinspired light‐driven rotary molecular systems (RMSs), highlighting the integration of natural chromophore‐based fragments to enhance quantum efficiency, photostability, and biocompatibility. Key strategies to optimize photochemical performance and broaden functional applications are discussed, providing a ...
Lidia Hortigüela, Sara P. Morcillo
wiley   +1 more source

Carbon and Heteroatom Activation via N‐Heterocyclic Carbene‐Bound Dearomative Intermediates for Stereoselective Annulation Reactions

Chemistry – A European Journal, EarlyView.
Use of N‐heterocyclic carbenes (NHCs) to activate carbon and heteroatoms in aromatic compounds is reviewed based on key dearomative NHC‐bound intermediates, i.e., ortho‐quinodimethanes (o‐QDMs), ortho‐quinone methides (o‐QMs) and aza‐analogs (aza‐o‐QMs), aza‐fulvene and triaza‐diene intermediates.
Carmela De Risi, Graziano Di Carmine, Daniele Ragno, Lorenzo Poletti, Alessandro Massi   +4 more
wiley   +1 more source

Role of RIM and VPS genes in pH signaling, virulence and resistance to antifungal drugs in the yeast Caandida albicans

, 2006
Murielle Gigou-Cornet
openalex   +1 more source

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Recent advances in antifungal drug development targeting lanosterol 14α‐demethylase (CYP51): A comprehensive review with structural and molecular insights

Chemical Biology and Drug Design, 2023
Fungal infections are posing serious threat to healthcare system due to emerging resistance among available antifungal agents. Among available antifungal agents in clinical practice, azoles (diazole, 1,2,4‐triazole and tetrazole) remained most effective ...
Atamjit Singh, Karanvir Singh, Aman Sharma, Kirandeep Kaur, R. Chadha, P. Bedi   +5 more
semanticscholar   +1 more source

Current applications and prospects of nanoparticles for antifungal drug delivery

EXCLI Journal : Experimental and Clinical Sciences, 2021
Currently, the significance of fungi as human pathogens is not medically concealed in the world. Consequently, suitable recognition and treatment of such infections are of great importance and necessitate the need for comprehensive information in this ...
Sanam Nami, Ali Aghebati-Maleki, L. Aghebati-Maleki   +2 more
semanticscholar   +1 more source

Antifungal Drugs

Pediatrics In Review, 1995
Introduction Fungi have been recognized as pathogens for many years. However, the incidence of fungal infections in the pediatric population has increased substantially due to the increased use of broad-spectrum antibiotics, immunosuppressive agents, hyperalimentation products, and central venous catheters in addition to the acquired ...
J T, Cross, S L, Hickerson, T, Yamauchi
openaire   +2 more sources