Results 141 to 150 of about 92,209 (296)

Development of novel HPTLC method for determination of imidazole antifungal drug fenticonazole: Exploring hydrotropy

, 2021
Amod S. Patil, Minakshi D. Pawara, Snehal Pardeshi, Amol R. Gaware, Manoj V. Girase   +4 more
openalex   +2 more sources

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Emerging Applications of Triazole Antifungal Drugs. [PDF]

Int J Mol Sci
Soldi LR, Oliveira APL, Silva MJB.
europepmc   +1 more source

Antibiotics in Combination with Antifungals to Combat Drug Resistant Candida – A Concept on Drug Repurposing

, 2020
Hannah Monalis, R. Sujith, K. V. Leela, V. Balamurali   +3 more
openalex   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

The Upcoming Antifungal Drugs in Clinical Development for the Treatment of Invasive Candidiasis. [PDF]

Infect Drug Resist
Zubovskaia A, Vazquez JA.
europepmc   +1 more source

Exploring synergy between azole antifungal drugs and statins for Candida auris. [PDF]

J Antimicrob Chemother, 2023
Halliday C, Kim HY, Tay E, Chen SCA, Alffenaar JW.   +4 more
europepmc   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Inhibition mechanism of the fungal β-1,3-glucan synthases by triterpenoid antifungal drugs. [PDF]

Nat Commun
You ZL, Sun L, Wang LX, Ni YR, Lyu RQ, Chen DD, Yun CH, Song T, Song Y, Bai L.   +9 more
europepmc   +1 more source