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Antifungal Drugs and Resistance
1995From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
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Fungal infections pose an important threat to public health and food security, and with the rise in antifungal drug and fungicide resistance, we are faced with a global crisis. Currently, humanity is at an intersection of global climate change driving the expansion of species range distributions, emergence of novel pathogenic fungi, and changing at ...
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1998
Abstract Amphotericin B has been the mainstay of systemic antifungal therapy for decades, but the toxicity associated with parenteral administration of the drug has led to a search for effective, less toxic, and more easily administered alternative drugs.
Peter G Pappas, John E Edwards
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Abstract Amphotericin B has been the mainstay of systemic antifungal therapy for decades, but the toxicity associated with parenteral administration of the drug has led to a search for effective, less toxic, and more easily administered alternative drugs.
Peter G Pappas, John E Edwards
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Organic Antifungal Drugs and Targets of Their Action
Current Topics in Medicinal Chemistry, 2021Sandeep Chaudhary, Irina Mashevskaya
exaly