Defective antifungal immunity in patients with COVID-19 [PDF]
Frontiers in Immunology, 2022 The COVID-19 pandemic has placed a huge strain on global healthcare and been a significant cause of increased morbidity and mortality, particularly in at-risk populations.
Juergen Loeffler +2 more
exaly +4 more sources
Neglected mycobiome in HIV infection: Alterations, common fungal diseases and antifungal immunity [PDF]
Frontiers in Immunology, 2022 Human immunodeficiency virus (HIV) infection might have effects on both the human bacteriome and mycobiome. Although many studies have focused on alteration of the bacteriome in HIV infection, only a handful of studies have also characterized the ...
Bin Su
exaly +4 more sources
Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathway [PDF]
Infection and ImmunityNon-receptor tyrosine kinase c-Abl is critical for host defense against bacterial and viral infections, yet its role in antifungal immunity remains elusive.
Yiheng Yang
exaly +4 more sources
Altered expression of genes related to innate antifungal immunity in the absence of galectin-3 [PDF]
Virulence, 2021 Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises β-galactoside-binding lectins and participates in several cellular events.
Thiago da Silva +2 more
exaly +3 more sources
Natural Killer Cells in Antifungal Immunity [PDF]
Frontiers in Immunology, 2017 Invasive fungal infections are still an important cause of morbidity and mortality in immunocompromised patients such as patients suffering from hematological malignancies or patients undergoing hematopoietic stem cell transplantion.
Thomas Lehrnbecher +2 more
exaly +4 more sources
Tissue-Resident Memory T Cells in Antifungal Immunity [PDF]
Frontiers in Immunology, 2021 Fungi are an integral part of the mammalian microbiota colonizing most if not all mucosal surfaces and the skin. Maintaining stable colonization on these surfaces is critical for preventing fungal dysbiosis and infection, which in some cases can lead to ...
Salomé LeibundGut-Landmann +1 more
doaj +2 more sources
Interleukin-17 in Antifungal Immunity [PDF]
Pathogens, 2019 The field of IL-17 biology has received much attention over the last decade owing to the pathogenic role of this cytokine in psoriasis and other autoinflammatory disorders and the successful implementation of IL-17-targeting therapies in patients ...
Florian Sparber +1 more
doaj +2 more sources
The role of nucleic acid sensors in antifungal immunity [PDF]
Frontiers in ImmunologyFungal infections pose a grave threat to individuals with compromised immune systems, and the accelerated proliferation of drug-resistant strains has led to a marked decline in the effectiveness of conventional antifungal medications in clinical settings.
Xinyu Liang +5 more
doaj +2 more sources
Cytosolic receptors and signaling in antifungal immunity [PDF]
The EMBO JournalThe host innate immune system provides the first line of protection against invading microbial pathogens, including fungi. Recognition of fungi by host pattern-recognition receptors (PRRs) is critical for their clearance. PRRs bind to pathogen-associated
Sandra Khau +4 more
doaj +2 more sources
Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice [PDF]
Frontiers in ImmunologyIntroductionThis study establishes and characterizes a novel experimental mouse model to evaluate Sporothrix brasiliensis infection under type 1 diabetic conditions, providing a comprehensive description of the associated clinicopathological and ...
Mariana Araujo Oliveira +5 more
doaj +2 more sources