Results 71 to 80 of about 3,341,399 (277)
, 2016 Some environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of ...
Stevens, David A. +5 more
core +1 more source
Advanced Science, EarlyView.The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan +10 more
wiley +1 more source
Antifungal susceptibility testing and resistance
, 2017 The availability of choice of systemically active antifungal agents and the proliferation in the number of fungal species implicated in invasive disease have meant that clinicians are increasingly looking for guidance from clinical laboratory results to ...
Elizabeth M. Johnson
core +1 more source
Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Current Medical Mycology, 2016 Background and Purpose: The incidence of fungal infection as well as candidemia has increased significantly, contributing to morbidity and mortality in the developed countries.
Partha Bhattacharjee
doaj
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
In vitro antifungal susceptibility testing of ocular filamentous fungal pathogens isolated from keratitis cases [PDF]
, 2022 Background: A variety of fungal species are known to cause keratitis. Filamentous fungi are often predominant cause of keratitis. As fungi belonging to different group usually differ in their pattern of susceptibility to antifungal agents commonly ...
Prachi Sudhir Dubal +2 more
core +1 more source
Changing trends of candidemia: A study from western Uttar Pradesh [PDF]
Journal of Krishna Institute of Medical Sciences University, 2023 Background: Candidemia is one of the common health care associated Blood Stream Infections (BSI). Frequency of isolation of various Candida species causing candidemia and their antifungal drug resistance trends in a health care setting can help in ...
Vidhi Kardam +2 more
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