Results 301 to 310 of about 1,150,155 (343)
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Structure, 2020
Accurate predictive modeling of antibody-antigen complex structures and structure-based antibody design remain major challenges in computational biology, with implications for biotherapeutics, immunity, and vaccines.
Johnathan D. Guest +7 more
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Accurate predictive modeling of antibody-antigen complex structures and structure-based antibody design remain major challenges in computational biology, with implications for biotherapeutics, immunity, and vaccines.
Johnathan D. Guest +7 more
semanticscholar +1 more source
Antigen-antibody complex as therapeutic vaccine for viral hepatitis B.
International Reviews of Immunology, 1999In a previous study, hepatitis B surface antigen (HBsAg) complexed to human anti-HBs immunoglobulins (HBIG) in excess of HBsAg was used as therapeutic vaccine to treat chronic hepatitis B patients and promising results were obtained.
Y. Wen, D. Qu, S. Zhou
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Experimental Antigen-Antibody Complex Disease in Mice
, 1982Chronic antigen-antibody complex disease (A-ACD) was induced in mice by daily injections of HSA. The disease was characterized by death, intense glomerular basement membrane deposition of complexes in the kidneys, proteinuria and an impairment of the ...
M. Devey +3 more
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Hepatitis B virus and antigen-antibody complex diseases.
New England Journal of Medicine, 1977Infection with the hepatitis B virus (HBV) can induce a variety of responses in human beings. Physicians generally think first of acute hepatitis, a disease characterized by a relatively long incubation period, the appearance in the blood, during the ...
W. London
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A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.
Biochemistry, 1998Alanine scanning mutagenesis, double mutant cycles, and X-ray crystallography were used to characterize the interface between the anti-hen egg white lysozyme (HEL) antibody D1.3 and HEL.
W. Dall'acqua +10 more
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Antibody–Drug Conjugates: A Comprehensive Review
Molecular Cancer Research, 2019Antibody–drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing ...
Puregmaa Khongorzul +4 more
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Factors affecting the antigen-antibody reaction.
Blood transfusion = Trasfusione del sangue, 2007The antigen-antibody reaction is widely used in laboratory diagnostics, including immunohaematology. It is a reversible chemical reaction: antigen+antibody⇄antigen-antibody complex (1) The forces joining the antigen-antibody complex are not ...
R. Reverberi, L. Reverberi
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On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5.
Biochemistry, 1989Using X-ray coordinates of antigen-antibody complexes McPC 603, D1.3, and HyHEL-5, we made semiquantitative estimates of Gibbs free energy changes (delta G) accompanying noncovalent complex formation of the McPC 603 Fv fragment with phosphocholine and ...
Jiří Novotný +2 more
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Long-range changes in a protein antigen due to antigen-antibody interaction.
Biochemistry, 1992Amide exchange kinetics were used to probe the conformation of hen egg-white lysozyme complexed with the anti-lysozyme monoclonal antibody HyHEL-5. Following the technique developed by Paterson et al. [(1990) Science 249, 755-759] we used two-dimensional
D. Benjamin +3 more
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Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution
Science, 1986A. Amit +3 more
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