Results 41 to 50 of about 2,402,498 (300)

Removal of serological interference in the treatment of multiple myeloma with CD38 monoclonal antibody using polybrene method

Zhongguo shuxue zazhi, 2022
Objective To investigate the clinical feasibility of polybrene method to remove serological interference in patients receiving anti-CD38 monoclonal antibody for the treatment of multiple myeloma, and its detection performance of alloantibodies.
Yan ZHENG, Wenting WANG, Shijie MU, Xia XIE, Qiong WANG   +4 more
doaj   +1 more source

Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?

Vaccines, 2022
During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making ...
Daniele Focosi, Massimo Franchini, Fabrizio Maggi   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Acute Hemolytic Transfusion Reaction Due to Anti-c Rhesus Antibody in a Patient With Subdural Hematoma: A Case Report Emphasizing the Shortcoming of Spin Cross-Match

Acta Medica Iranica, 2020
The Rh blood group system is a complex blood group which includes different antigen specificities such as c antigen. Anti-c antibody is associated with both acute and delayed hemolytic transfusion reactions as well as hemolytic disease of the newborn ...
Hamid Reza Niazkar, Mohammad Ghorbani, Mohsen Saheban Maleki, Hossein Jahangir, Farhad Homapour, Abbasali Abbasnezhad   +5 more
doaj   +1 more source

IgY Antibodies from Birds: A Review on Affinity and Avidity

Animals, 2023
IgY antibodies are found in the blood and yolk of eggs. Several studies show the feasibility of utilising IgY for immunotherapy and immunodiagnosis. These antibodies have been studied because they fulfil the current needs for reducing, replacing, and ...
Bianca Lisley Barboza Pacheco, Camila Parada Nogueira, Emerson José Venancio   +2 more
doaj   +1 more source

Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism.
Drew, Damien R., Anders, Robin, Sheetij Dutta, Cross, Nadia, Senn, Nicolas, Hodder, AN, Dutta, Sheetij, Nicolas Senn, Osier, Faith H. A., Terheggen, Ulrich, Hodder, Anthony, Damien R Drew, Beeson, JG, Nadia J Cross, James G Beeson, Mugyenyi, Cleopatra, Osier, FHA, Alyssa E Barry, Ulrich Terheggen, Hodder, Anthony N., Barry, Alyssa, Siba, Peter, Mueller, I, Siba, PM, Beeson, James, Drew, DR, Stanisic, Danielle I., Terheggen, U, Anders, RF, Beeson, James G., Peter M Siba, Dutta, S, Cross, Nadia J., Stanisic, Danielle, Kevin Marsh, Faith HA Osier, Elliott, Salenna, Barry, AE, Jack S Richards, Anders, Robin F., Barry, Alyssa E., Elliott, Salenna R., Senn, N, Danielle I Stanisic, Stanisic, DI, Mueller, Ivo, Richards, Jack, Ivo Mueller, Marsh, K, Elliott, SR, Richards, Jack S., Drew, Damien, Anthony N Hodder, Mugyenyi, Cleopatra K., Cleopatra K Mugyenyi, Osier, Faith, Richards, JS, Robin F Anders, Cross, NJ, Salenna R Elliott, Marsh, Kevin, Mugyenyi, CK, Siba, Peter M.   +62 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Generation and application of recombinant antibody fragments for prostate cancer detection. [PDF]

, 2010
Prostate cancer (PCa) is the most prevalent adenocarcinoma and the second highest cause of cancer-related deaths in men. Early diagnosis is required to identify the development of PCa to reduce the risk of the disease metastasising to different regions ...
Hayes, Conor
core   +1 more source

The anti-Mia antibody – Report of four cases in a tertiary care hospital with review of literature

Global Journal of Transfusion Medicine, 2019
Anti – Mia antibody is antibody reacting with Mi III phenotype of the Miltenberger (Mi) subsystem. It is rarely reported in the West, however, it is common in Chinese and South East Asian populations. Very few cases have been reported in India.
Sangeeta Pahuja, Shivali Sehgal, Geetika Sharma, Manisha Singh, Ramvilash Yadav   +4 more
doaj   +1 more source