Tetraspanins as Organizers of Antigen-Presenting Cell Function [PDF]
Frontiers in Immunology, 2018 Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger ...
Maria Laura Saiz +6 more
doaj +3 more sources
Novel antigen-presenting cell imparts T<sub>reg</sub>-dependent tolerance to gut microbiota. [PDF]
Nature, 2022 Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical ...
Akagbosu B +22 more
europepmc +2 more sources
Size-transformable antigen-presenting cell-mimicking nanovesicles potentiate effective cancer immunotherapy. [PDF]
Sci Adv, 2020 We provide a generalizable approach of using size-transformable artificial antigen-presenting cells for cancer immunotherapy. Artificial antigen-presenting cells (aAPCs) can stimulate CD8+ T cell activation.
Yang W +11 more
europepmc +2 more sources
Antigen-Presenting Cells in Psoriasis [PDF]
Life, 2022 Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal +4 more
doaj +3 more sources
Time-Dependent Serial Changes of Antigen-Presenting Cell Subsets in the Ocular Surface Are Distinct between Corneal Sterile Inflammation and Allosensitization in a Murine Model [PDF]
Cells, 2021 The kinetics of antigen-presenting cells (APCs) vary depending on their resident tissues and the manner of immunization. We investigated the long-term changes in mature APC and T-cell subsets over 4 weeks in the ocular surface in murine models of corneal
Kyoung-Woo Kim +3 more
doaj +2 more sources
Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. [PDF]
PLoS ONE, 2020 Adoptive cell transfer of Chimeric Antigen Receptor (CAR)-T cells showed promising results in patients with B cell malignancies. However, the detailed mechanism of CAR-T cell interaction with the target tumor cells is still not well understood. This work
Qassim Dirar +7 more
doaj +2 more sources
Role of B cells as antigen presenting cells
Frontiers in Immunology, 2022 B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity.
Ichwaku Rastogi +5 more
semanticscholar +4 more sources
Editorial: Insights in antigen presenting cell biology: 2021 [PDF]
Frontiers in Immunology, 2022 Peter van Endert, Peter van Endert
doaj +2 more sources
Editorial: Insights in antigen presenting cell biology: 2022 [PDF]
Frontiers in Immunology, 2023 Peter van Endert, Peter van Endert
doaj +2 more sources
Development of Mannose-Modified Carboxylated Curdlan-Coated Liposomes for Antigen Presenting Cell Targeted Antigen Delivery [PDF]
Pharmaceutics, 2020 Specific delivery to antigen presenting cells (APC) and precise control of the intracellular fate of antigens are crucial to induce cellular immunity that directly and specifically attacks cancer cells.
Eiji Yuba +4 more
doaj +2 more sources