Tetraspanins as Organizers of Antigen-Presenting Cell Function [PDF]
Frontiers in Immunology, 2018 Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger ...
Maria Laura Saiz +6 more
doaj +3 more sources
Novel antigen-presenting cell imparts T<sub>reg</sub>-dependent tolerance to gut microbiota. [PDF]
Nature, 2022 Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical ...
Akagbosu B +22 more
europepmc +2 more sources
Size-transformable antigen-presenting cell-mimicking nanovesicles potentiate effective cancer immunotherapy. [PDF]
Sci Adv, 2020 We provide a generalizable approach of using size-transformable artificial antigen-presenting cells for cancer immunotherapy. Artificial antigen-presenting cells (aAPCs) can stimulate CD8+ T cell activation.
Yang W +11 more
europepmc +2 more sources
Definitions, 2020 A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen presenting cell.
openaire +2 more sources
T cell antigen discovery via signaling and antigen-presenting bifunctional receptors [PDF]
Nature Methods, 2019 CD8^+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, the identification of target antigens remains a challenge.
Baltimore, David +11 more
core +5 more sources
Time-Dependent Serial Changes of Antigen-Presenting Cell Subsets in the Ocular Surface Are Distinct between Corneal Sterile Inflammation and Allosensitization in a Murine Model [PDF]
Cells, 2021 The kinetics of antigen-presenting cells (APCs) vary depending on their resident tissues and the manner of immunization. We investigated the long-term changes in mature APC and T-cell subsets over 4 weeks in the ocular surface in murine models of corneal
Kyoung-Woo Kim +3 more
doaj +2 more sources
Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. [PDF]
PLoS ONE, 2020 Adoptive cell transfer of Chimeric Antigen Receptor (CAR)-T cells showed promising results in patients with B cell malignancies. However, the detailed mechanism of CAR-T cell interaction with the target tumor cells is still not well understood. This work
Qassim Dirar +7 more
doaj +2 more sources
Antigen-Presenting Cells in Psoriasis [PDF]
Life, 2022 Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal +4 more
doaj +3 more sources
Editorial: Insights in antigen presenting cell biology: 2021 [PDF]
Frontiers in Immunology, 2022 Peter van Endert, Peter van Endert
doaj +2 more sources
Editorial: Insights in antigen presenting cell biology: 2022 [PDF]
Frontiers in Immunology, 2023 Peter van Endert, Peter van Endert
doaj +2 more sources