Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. [PDF]
, 1984 Michael A. Norcross +3 more
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma
Journal of Experimental & Clinical Cancer ResearchBackground Pancreatic ductal adenocarcinoma tumors exhibit resistance to chemotherapy, targeted therapies, and even immunotherapy. Dendritic cells use glucose to support their effector functions and play a key role in anti-tumor immunity by promoting ...
Bo Zhang +13 more
doaj +1 more source
Sensitization of human lymphocytes in vitro: genetic restriction of secondary T cell responses is dictated by the HLA-DR phenotype of antigen-presenting cells. [PDF]
, 1982 Dennis Ford +2 more
openalex +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis. [PDF]
Front Immunol, 2023 Zhang T +10 more
europepmc +1 more source
Lymphokine-mediated induction of antigen-presenting ability in thymic stromal cells. [PDF]
, 1987 John Ransom +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Next-generation antigen-presenting cell immune therapeutics for gliomas. [PDF]
J Clin Invest, 2023 Lee-Chang C, Lesniak MS.
europepmc +1 more source
Phosphorylation of the CD8 antigen on cytotoxic human T cells in response to phorbol myristate acetate or antigen-presenting B cells. [PDF]
, 1987 R B Acres +3 more
openalex +1 more source