Results 191 to 200 of about 2,709,177 (395)

Gas Plasma Protein Oxidation Increases Immunogenicity and Human Antigen-Presenting Cell Maturation and Activation. [PDF]

Vaccines (Basel), 2022
Clemen R, Arlt K, von Woedtke T, Bekeschus S.   +3 more
europepmc   +1 more source

Defective T cell response to presented antigen in autoimmune mice. [PDF]

, 1984
Michael A. Fischbach
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors. [PDF]

Nat Commun, 2023
Adu-Berchie K, Brockman JM, Liu Y, To TW, Zhang DKY, Najibi AJ, Binenbaum Y, Stafford A, Dimitrakakis N, Sobral MC, Dellacherie MO, Mooney DJ.   +11 more
europepmc   +1 more source

Processing and presentation of insulin. II. Evidence for intracellular, plasma membrane-associated and extracellular degradation of human insulin by antigen-presenting B cells. [PDF]

, 1989
John W. Semple, James Ellis, T L Delovitch   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. [PDF]

, 1986
K Sertl, Tamiko Takemura, Erwin Tschachler, V J Ferrans, Michael Kaliner, Ethan M. Shevach   +5 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Next-generation pathology detection of T cell-antigen-presenting cell immune synapses in human liver allografts. [PDF]

Hepatology, 2023
Wood-Trageser MA, Lesniak D, Gambella A, Gambella A, Golnoski K, Feng S, Bucuvalas J, Sanchez-Fueyo A, Demetris AJ.   +8 more
europepmc   +1 more source

IMPAIRMENT OF ANTIGEN-PRESENTING CELL FUNCTION BY ULTRAVIOLET RADIATION II. EFFECT OF IN VITRO ULTRAVIOLET IRRADIATION ON ANTIGEN-PRESENTING CELLS

, 1981
Ira J. Fox, Man‐Sun Sy, Baruj Benacerraf, Mark I. Greene   +3 more
openalex   +1 more source