Results 21 to 30 of about 416,035 (333)

Vaccine delivery using nanoparticles

Frontiers in Cellular and Infection Microbiology, 2013
Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive.
Anthony Edward Gregory, Diane eWilliamson, Richard eTitball   +2 more
doaj   +1 more source

CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells

BMC Immunology, 2023
Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn, Tai-Gyu Kim   +3 more
doaj   +1 more source

Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene. [PDF]

, 2015
The aim of the present study was to enhance the efficiency of leukemia immunotherapy by increasing the antigen-specific cytotoxic T lymphocyte-inducing ability of leukemia cells. The leukemic plasmacytoid dendritic cell line PMDC05 containing the HLA-A02/
Bonehill, Aude, Hashimoto, Shigeo, Iwabuchi, Minami, Iwaya, Shunpei, Kasahara, Noriyuki, Narita, Miwako, Nishizawa, Yoshinori, Oiwa, Eri, Takahashi, Masuhiro, Takizawa, Jun, Uchiyama, Takayoshi   +10 more
core   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells [PDF]

International Journal of Molecular Sciences, 2021
Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells, fibroblasts, and lymph node stromal cells, are also capable of presenting exogenous antigens to either CD8+ or CD4+ T cells via cross ...
Tom J. Harryvan, Sabine de Lange, Lukas J.A.C. Hawinkels, Els M.E. Verdegaal   +3 more
openaire   +3 more sources

Antigen-specific T cell activation independently of the MHC: chimeric antigen receptor (CAR)-redirected T cells.

Frontiers in Immunology, 2013
Adoptive T cell therapy has recently shown powerful in initiating a lasting anti-tumor response with spectacular therapeutic success in some cases. Specific T cell therapy, however, is limited since a number of cancer cells are not recognized by T cells ...
Hinrich eAbken, Hinrich eAbken, Markus eChmielewski, Andreas A. Hombach   +3 more
doaj   +1 more source

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Alon, Bell, Bell, Bromley, Brown, Carlin, Christoph Wülfing, Dai, Davis, Dembo, Donnadieu, Dustin, Dustin, Dustin, Evans, Favier, Forscher, Fritz, Grakoui, Hahn, Janes, Janeway, Johnson, Johnson, Krummel, Lauffenburger, Le Grimellec, Leupin, Lollo, Lyons, McNeill, Monks, Moy, Needham, Nigel John Burroughs, Orsello, Pathria, Pierres, Qi, Raucher, Raucher, Rotsch, Rudd, Ryan, Schreiner, Shao, Simons, Strey, Taylor, van der Merwe, Viola, Wild, Wülfing, Wülfing, Wülfing   +54 more
core   +2 more sources

Antigen presentation by Langerhans cells [PDF]

Current Opinion in Immunology, 2013
Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response.
Daniel H. Kaplan, Botond Z. Igyártó
openaire   +3 more sources

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

Haematologica, 2008
Background Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy.
Roberta Zappasodi, Massimo Di Nicola, Carmelo Carlo-Stella, Roberta Mortarini, Alessandra Molla, Claudia Vegetti, Salvatore Albani, Andrea Anichini, Alessandro M. Gianni   +8 more
doaj   +1 more source

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources