Results 21 to 30 of about 2,709,177 (395)

Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation

eLife, 2022
In allergic asthma, allergen inhalation leads to local Th2 cell activation and peribronchial inflammation. However, the mechanisms for local antigen capture and presentation remain unclear.
Xin-Zi Tang, Lieselotte S M Kreuk, Cynthia Cho, Ross J Metzger, Christopher D C Allen   +4 more
doaj   +1 more source

Antigen Presenting Cell

Definitions, 2020
A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen presenting cell.

semanticscholar   +1 more source

Enhancing Protective Efficacy of Poultry Vaccines through Targeted Delivery of Antigens to Antigen-Presenting Cells

Vaccines, 2018
Avian viral diseases including avian influenza, Marek’s disease and Newcastle disease are detrimental to economies around the world that depend on the poultry trade.
Angita Shrestha, Jean-Remy Sadeyen, Munir Iqbal   +2 more
doaj   +1 more source

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Journal of Experimental Medicine, 2020
Low et al. compare the reactivation of memory CD8+ T cells resident in the lung or draining lymph node after a secondary influenza infection and find that memory T cells in the different anatomical locations have unique reactivation mechanics in terms of
J. Low, Yagmur Farsakoglu, M. C. Amezcua Vesely, Esen Sefik, Joseph B. Kelly, Christian C. D. Harman, Ruaidhri Jackson, J. Shyer, Xiaodong Jiang, L. Cauley, R. Flavell, S. Kaech   +11 more
semanticscholar   +1 more source

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts.

Cancer Discovery, 2019
Cancer-associated fibroblasts (CAFs) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of ...
Ela Elyada, M. Bolisetty, Pasquale Laise, W. Flynn, Elise T. Courtois, R. Burkhart, J. Teinor, P. Belleau, Giulia Biffi, M. Lucito, S. Sivajothi, T. Armstrong, Dannielle D. Engle, Kenneth H. Yu, Yuan Hao, elliot k fishman, Youngkyu Park, Jonathan Preall, E. Jaffee, A. Califano, P. Robson, D. Tuveson   +21 more
semanticscholar   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

Vaccine delivery using nanoparticles

Frontiers in Cellular and Infection Microbiology, 2013
Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive.
Anthony Edward Gregory, Diane eWilliamson, Richard eTitball   +2 more
doaj   +1 more source

Modulation of antigen-specific T-cells as immune therapy for chronic infectious diseases and cancer [PDF]

, 2014
Copyright: © 2014 Li, Symonds, Miao, Sanderson and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Abraham, Ahmadzadeh, Akbar, Anderson, Baine, Barber, Baur, Belkaid, Bensinger, Bergmann, Berzofsky, Blackburn, Brooks, Brooks, Brooks, Colonna, Das, Day, Duraiswamy, Ejrnaes, Frebel, Geijtenbeek, Guidotti, Ha, Jerome, Jung, Kasprowicz, Kaufmann, Kim, Klein, Kroemer, Kroy, Larsson, Liu, Lu, Maizels, Malek, Matsuzaki, Mier, Mumprecht, Nandedkar, Nurieva, Nurieva, Ramsay, Schietinger, Schwartz, Sofra, Soldaini, Steinman, Trautmann, Vezys, Waggoner, Wedemeyer, Wilson, Yi, Zhou   +55 more
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CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells

BMC Immunology, 2023
Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn, Tai-Gyu Kim   +3 more
doaj   +1 more source

Antigen depot is not required for alum adjuvanticity [PDF]

, 2012
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation
Abigail H. Pollock, Brewer J. M., Holt L. B., James M. Brewer, Murphy D. B., Oakley C. L., Paul Garside, Robert A. Benson, Rush C. M., Sharon Hutchison, Vivienne B. Gibson, Ziegler S. F.   +11 more
core   +2 more sources