Results 291 to 300 of about 416,035 (333)

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

, 1998
Hans Häcker, Harald Mischak, Thomas Miethke, Susanne Liptay, Roland M. Schmid, Tim Sparwasser, Klaus Heeg, Grayson B. Lipford, Hermann Wagner   +8 more
openalex   +2 more sources

A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation

Advanced Functional Materials, EarlyView.
This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou, Supun Ranaweera, Xiangke Li, Ruirui Qiao, Yue Hui, Chun‐Xia Zhao   +5 more
wiley   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

From Exciton Dynamics to Cell Fate: A Carbon Dot Based NIR Photocatalytic Platform for Pyroptosis via Self‐Trapped Excitons

Advanced Functional Materials, EarlyView.
A facile and effective method to boost NIR light induced photocatalysis based on nontoxic NIR emissive carbon dots (nir‐CDs) via Self‐trapped excitons, showing that both O2− • and •OH can be generated from nir‐CDs under NIR laser irradiation. Abstract Near‐infrared (NIR) light‐triggered photocatalytic therapy remains a critical challenge in efficient ...
Qingcheng Wang, Quansheng Cheng, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Ruifeng Zheng, Shi Chen, Guichuan Xing, Songnan Qu   +8 more
wiley   +1 more source

Wafer‐Scale Integration of α‐quartz Thin Films toward Super High Frequency Piezoelectric bioNEMS for Chikungunya Virus Detection

Advanced Functional Materials, EarlyView.
Epitaxial piezoelectric α‐quartz/Si BioNEMS sensors, made using soft chemistry, effectively detect the Chikungunya virus. They have a mass sensitivity of 205 pg Hz−1 in liquid and can detect the virus at a limit of 9 ng mL−1. This development enables high‐frequency mass devices for point‐of‐care testing in healthcare and other electronic applications ...
Raissa Rathar, Sijie Ding, David Sanchez‐Fuentes, Claire Jolly, Charlotte André‐Arpin, Rudy Desgarceaux, Nicolas Guillaume, Gustavo Ardila, Ricardo Garcia‐Bermejo, Jaume Gazquez, Sergi Plana‐Ruiz, Laura Picas, Adrian Carretero‐Genevrier   +12 more
wiley   +1 more source