Results 301 to 310 of about 416,035 (333)

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Intraperitoneal administration of immunogenic Toll‐like receptor agonist‐modified mesoporous silica nanoparticles leads to rapid internalization by ascites myeloid cells with trafficking to fat‐associated lymphoid clusters. Activation of myeloid cells counters suppressive immune mechanisms associated with peritoneal metastasis, leading to regional and ...
Ben Marwedel, Henning De May, Lauren Anderson, Lorél Y. Medina, Ellie Kennedy, Erica Flores, John O'Rourke, Marian Olewine, Irina Lagutina, Lillian Fitzpatrick, Fred Shultz, Donna F. Kusewitt, Eric Bartee, Sarah Adams, Achraf Noureddine, Rita E. Serda   +15 more
wiley   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

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T cells as antigen-presenting cells

Immunology Today, 1994
Human T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting cells (APCs), and recent in vitro and in vivo evidence supports an antigen-presenting function for T cells. In this guise, T cells provide downregulatory signals for the immune response by inducing anergy in T cells
Werner J. Pichler, Tony Wyss-Coray
openaire   +3 more sources

Basophils as antigen presenting cells

Trends in Immunology, 2010
Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites. Through MHC class II-dependent cognate interactions with CD4(+) T cells in the context of co-stimulatory molecules, and through secretion of IL-4, IL-13 and thymic stromal lymphopoietin,
Maddur, Mohan, Kaveri, Srini, Bayry, Jagadeesh   +2 more
openaire   +4 more sources

Antigen presenting cells

Immunologic Research, 1989
A great deal has been learned over the past few years regarding the molecular biology of antigen presentation. These discoveries have been possible in part because of acquisition of protein sequencing data regarding class I and class II MHC molecules and in part because of X-ray crystallographic analysis of the three-dimensional structures of these ...
openaire   +3 more sources

Antigen Presentation to B Cells

Trends in Immunology, 2016
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors.
Michael C. Carroll, Abhishek Das, Balthasar A. Heesters, Cees E. van der Poel   +3 more
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Antigen-presenting cell types

Current Opinion in Immunology, 1993
Different antigen-presenting cells elicit responses in different T-cell populations for primary activation, secondary stimulation and cytotoxic effector functions. Maturing bone marrow derived dendritic cells may acquire and process antigens, transport them to lymph nodes and activate naive T cells located there. By contrast, follicular dendritic cells,
Andrew J. Stagg, Stella C. Knight
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Cell biology of antigen presentation

Current Opinion in Immunology, 1993
MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference.
Frank Momburg, Frank Momburg, Jacques Neefjes   +2 more
openaire   +2 more sources

Antigen presentation, antigen-presenting cells and antigen processing

Current Opinion in Immunology, 1988
To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the antigen.
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Antigen-presenting cells in allergy

Journal of Allergy and Clinical Immunology, 2001
The complex interaction of the innate and adaptive immune system requires flexibility and cooperation among various cell types. In this regard, antigen-presenting-cells (APCs) play a pivotal role in transferring information from the periphery of the organism to lymphoid organs, where they initiate the activation of naive T cells.
Thomas Bieber, Dagmar von Bubnoff, Elisabeth Geiger   +2 more
openaire   +3 more sources