Results 31 to 40 of about 2,709,177 (395)
Nature Communications, 2019 Both medullary thymic epithelial cells (mTEC) and dendritic cells (DC) present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the relative contributions of these antigen-presenting cell (APC) subsets remain unresolved ...
Jessica N. Lancaster +5 more
semanticscholar +1 more source
Frontiers in Immunology, 2013 Adoptive T cell therapy has recently shown powerful in initiating a lasting anti-tumor response with spectacular therapeutic success in some cases. Specific T cell therapy, however, is limited since a number of cancer cells are not recognized by T cells ...
Hinrich eAbken +3 more
doaj +1 more source
Granulocytes: New Members of the Antigen-Presenting Cell Family
Frontiers in Immunology, 2017 Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in ...
Ang Lin, K. Loré
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Immunosuppressive Tregs constitutively express CTLA-4, an immune checkpoint receptor. Addressing the role of CTLA-4 in Treg-suppressive function, we show that Treg-expressed CTLA-4, even in the absence of its cytoplasmic portion, promoted ...
Murat Tekguc +4 more
semanticscholar +1 more source
The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells [PDF]
International Journal of Molecular Sciences, 2021 Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells, fibroblasts, and lymph node stromal cells, are also capable of presenting exogenous antigens to either CD8+ or CD4+ T cells via cross ...
Tom J. Harryvan +3 more
openaire +3 more sources
Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene. [PDF]
, 2015 The aim of the present study was to enhance the efficiency of leukemia immunotherapy by increasing the antigen-specific cytotoxic T lymphocyte-inducing ability of leukemia cells. The leukemic plasmacytoid dendritic cell line PMDC05 containing the HLA-A02/
Bonehill, Aude +10 more
core +1 more source
Antigen presentation by Langerhans cells [PDF]
Current Opinion in Immunology, 2013 Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response.
Daniel H. Kaplan, Botond Z. Igyártó
openaire +3 more sources
Targeting antigens to dendritic cell receptors for vaccine development [PDF]
, 2013 Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance.
Apostolopoulos, Vasso +3 more
core +2 more sources
Haematologica, 2008 Background Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy.
Roberta Zappasodi +8 more
doaj +1 more source
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.
Journal of Immunology, 1991 Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell clones when they are activated under conditions requiring the presence of APC. By preincubating APC with IL-10, we demonstrate that IL-10 acts principally on APC
D. Fiorentino +6 more
semanticscholar +1 more source