Results 81 to 90 of about 2,709,177 (395)

The second touch hypothesis: T cell activation, homing and polarization [v2; ref status: indexed, http://f1000r.es/3zq]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Journal of Neuroinflammation, 2020
Background Many lines of evidence suggest that accumulation of aggregated alpha-synuclein (αSYN) in the Parkinson’s disease (PD) brain causes infiltration of T cells.
Jinar Rostami, Grammatiki Fotaki, Julien Sirois, Ropafadzo Mzezewa, J. Bergström, M. Essand, Luke M. Healy, A. Erlandsson   +7 more
semanticscholar   +1 more source

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation [PDF]

The Journal of Immunology, 2006
Abstract Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work,
Raimondi, G, ZANONI, IVAN, CITTERIO, STEFANIA, CASTAGNOLI, PAOLA, GRANUCCI, FRANCESCA   +4 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Antigen Presenting Cells Instruct Plasma Cell Differentiation

Frontiers in Immunology, 2014
The professional antigen presenting cells (APCs), including many subsets of dendritic cells and macrophages, not only mediate prompt but nonspecific response against microbes, but also bridge the antigen-specific adaptive immune response through antigen ...
Wei eXu, Jacques eBanchereau
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +5 more sources