Results 91 to 100 of about 6,495,314 (227)

TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

Cell Reports, 2012
Viruses can escape cytotoxic T cell (CTL) immunity by avoiding presentation of viral components via endogenous MHC class I antigen presentation in infected cells.
Dirk Wohlleber, Hamid Kashkar, Katja Gärtner, Marianne K. Frings, Margarete Odenthal, Silke Hegenbarth, Carolin Börner, Bernd Arnold, Günter Hämmerling, Bernd Nieswandt, Nico van Rooijen, Andreas Limmer, Karin Cederbrant, Mathias Heikenwalder, Manolis Pasparakis, Ulrike Protzer, Hans-Peter Dienes, Christian Kurts, Martin Krönke, Percy A. Knolle   +19 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes

, 2012
For autoimmune conditions like type 1 diabetes to progress, self-reactive CD8⁺ T cells would need to interact with peptide-antigen cross-presented on the surface of antigen-presenting cells in a major histocompatibility complex (MHC) class I-restricted ...
Eliana Mariño, Lauren Binge, Charles R. Mackay, Tan, B., Grey, S.T., Shane T. Grey, Bernice Tan, Mackay, C.R., Mariño, E., Binge, L.   +9 more
core   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]

, 1992
Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Koszinowski, Ulrich H., Hartlaub, Udo, T Ruppert, U H Koszinowski, H Hengel, Del Val, Margarita, Lucin, Pero, U Hartlaub, M del Val, P Lucin, Häcker, Hans, Ruppert, Thomas, H Häcker, Hengel, Hartmut   +13 more
core   +1 more source

Into the intracellular logistics of cross-presentation

Frontiers in Immunology, 2012
The induction of cytotoxic CD8+ T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins.
Charlotte eSadaka, Jacques eNeefjes
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation

Scientific Reports, 2017
TOLL-like receptor (TLR) ligands activate both innate and adaptive immune cells, while modulating the cellular immune response. The outer membrane protein (OMP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an ...
Michael L. Reiser, Munir M. Mosaheb, Christina Lisk, Andrew Platt, Lee M. Wetzler   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

IgE/FcεRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses

Cell Reports, 2015
Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood.
Barbara Platzer, Kutlu G. Elpek, Viviana Cremasco, Kristi Baker, Madeleine M. Stout, Cornelia Schultz, Eleonora Dehlink, Kai-Ting C. Shade, Robert M. Anthony, Richard S. Blumberg, Shannon J. Turley, Edda Fiebiger   +11 more
doaj   +1 more source