Results 121 to 130 of about 6,495,314 (227)

Sec61 mediates antigen translocation into the cytosol for cross-presentation [PDF]

, 2016
The mechanisms regulating non canonical protein transport across cellular membranes are poorly understood. Cross-presentation of exogenous antigens on MHC I by dendritic cells generally require antigen translocation from the endosomal compartment into ...
Zehner, Matthias
core   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source

Artemisinin‐Loaded Core‐Shell Microspheres Modulate Histone Lactylation to Remodel the Microenvironment for Cartilage Protection in Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng, Jianxin Li, Yuyang Luo, Yisi Liu, Feng Xing, Yingchen Ni, Fengyuan Zhang, Zhicheng Fan, Hua Xu, Weidong Zhang, Youhua Wang   +10 more
wiley   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

dendritic cells in cross-presentation is not dictated by antigen capture

, 2006
Mouse spleens contain three populations of conventional (CD11c ) dendritic cells (DCs) that play distinct functions. The CD8 DC are unique in that they can present exogenous antigens on their MHC class I molecules, a process known as cross-presentation ...
Carbone, Francis R., Petra Schnorrer, Fiona Kupresanin, Ming Li, Li, Ming, Smith, Christopher M., Behrens, Georg M. N., Shortman, Ken, Villadangos, Jose A., Joanne L. Pooley, Davey, Gayle, Gabrielle T. Belz, Belz, Gabrielle T., Maraskovsky, Eugene, Wilson, Nicholas S., Dima El-Sukkari, Jose A. Villadangos, Christopher M. Smith, Eugene Maraskovsky, Kupresanin, Fiona, Heath, William R., Georg M. N. Behrens, Francis R. Carbone, Gayle Davey, El-Sukkari, Dima, William R. Heath, Pooley, Joanne L., Ken Shortman, Schnorrer, Petra, Nicholas S. Wilson   +29 more
core   +1 more source

MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C

iScience
Summary: In addition to cross-presentation, cross-dressing plays an important role in the induction of CD8+ T cell immunity. In the process of cross-dressing, conventional dendritic cells (DCs) acquire major histocompatibility complex class I (MHCI) from
Arisa Hori, Saori Toyoura, Miyu Fujiwara, Ren Taniguchi, Yasutaka Kano, Tomoyoshi Yamano, Rikinari Hanayama, Masafumi Nakayama   +7 more
doaj   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

, 2010
Vaccines aiming to activate cytotoxic T cells require cross-presentation of exogenous antigen by antigen-presenting cells (APCs). We recently developed a synthetic nanoparticle vaccine platform that targets lymph node-resident dendritic cells (DCs ...
van der Vlies AJ, Sachiko Hirosue, Swartz MA, Kourtis IC, Jeffrey A. Hubbell, Melody A. Swartz, André J. van der Vlies, Iraklis C. Kourtis, Hirosue S, Hubbell JA   +9 more
core   +1 more source