Results 51 to 60 of about 3,953,720 (287)

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Antigen-Specific Gene Therapy after Immunisation Reduces the Severity of Collagen-Induced Arthritis

Clinical and Developmental Immunology, 2013
Reestablishment of tolerance induction in rheumatoid arthritis (RA) would be an optimal treatment with few, if any, side effects. However, to develop such a treatment further insights in the immunological mechanisms governing tolerance are needed.
Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Louise Henningsson, Rikard Holmdahl, Kenth Gustafsson, Inger Gjertsson   +6 more
doaj   +1 more source

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis

Frontiers in Immunology, 2022
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Mühl-Zürbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Meik Kunz, Tobias Bäuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer   +17 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells

Arthritis Research & Therapy, 2018
Background Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic inflammatory diseases.
Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior, Fernando de Queiroz Cunha   +12 more
doaj   +1 more source

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. [PDF]

PLoS ONE, 2015
AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase critically involved in the regulation of cellular energy homeostasis. It is a central regulator of both lipid and glucose metabolism.
Monica Guma, Yun Wang, Benoit Viollet, Ru Liu-Bryan   +3 more
doaj   +1 more source

Standardization of Antigen-Emulsion Preparations for the Induction of Autoimmune Disease Models

Frontiers in Immunology, 2022
Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund’s adjuvant is commonly used to induce disease in autoimmune models, and the quality of the adjuvant ...
Louise M. Topping, Laura Romero-Castillo, Vilma Urbonaviciute, Hans Bolinsson, Felix I. Clanchy, Felix I. Clanchy, Rikard Holmdahl, B. Thomas Bäckström, B. Thomas Bäckström, Richard O. Williams   +9 more
doaj   +1 more source

Arthritis and disability [PDF]

, 2014
Executive summary: Arthritis Australia commissioned the Social Policy Research Centre (SPRC) at UNSW Australia to carry out research on the lived experience of people with arthritis related conditions.
Shona Bates, Karen Fisher, Fisher, KR ; https://orcid.org/, Bates, S ; https://orcid.org/, Smedley, C, Wong, M ; https://orcid.org/, Melissa Wong, Rosemary Kayess, Charlotte Smedley, Kayess, R   +9 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner

Frontiers in Immunology, 2019
Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis.
Dmytro Royzman, Darja Andreev, Lena Stich, Manfred Rauh, Tobias Bäuerle, Stephan Ellmann, Louis Boon, Markus Kindermann, Katrin Peckert, Aline Bozec, Georg Schett, Alexander Steinkasserer, Elisabeth Zinser   +12 more
doaj   +1 more source