Results 41 to 50 of about 3,953,720 (287)

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]

, 2014
Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa, Pineda, Miguel A, Rodgers, David T, Harnett, Margaret, Harnett, William   +4 more
core   +3 more sources

Modulation of granulocyte-endothelium interactions by antileukoproteinase : inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium [PDF]

, 2006
Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity.
Rikard Holmdahl, Kutty Nandakumar, Vollmar, Brigitte,, Sehnert, Bettina,, Harald Burkhardt, Rupert Hallmann, Hallmann, Rupert,, Anja Kühl, Reinhard Voll, Ibrahim, Saleh, Nandakumar, Kutty Selva,, Holmdahl, Rikard, Voll, Reinhard,, Burkhardt, Harald,, Gierer, Philip,, Bettina Sehnert, Burkhardt, Harald, Hallmann, Rupert, Saleh Ibrahim, Nandakumar, Kutty Selva, Vollmar, Brigitte, Ibrahim, Saleh,, Kühl, Anja,, Kuehl, Anja, Sehnert, Bettina, Philip Gierer, Gierer, Philip, Kühl, Anja, Lund University., Voll, Reinhard, Holmdahl, Rikard,, Brigitte Vollmar   +31 more
core   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Klareskog, Lars, Lars Klareskog, Rikard Holmdahl, Kallberg, H, Padyukov, L, Lars Alfredsson, Harald Burkhardt, Padyukov, Leonid, Olsson, Lina, Holmdahl, Rikard, Lina M Olsson, Burkhardt, H, Anna-Karin Lindqvist, Leonid Padyukov, Lindqvist, Anna-Karin,, Burkhardt, Harald, Klareskog, L, Lindqvist, Anna-Karin, Olsson, Lina M., Henrik Källberg, Olsson, Lina,, Källberg, Henrik, Alfredsson, Lars, Alfredsson, L, Lund University., Holmdahl, Rikard,   +25 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Interferon alpha inhibits antigen-specific production of proinflammatory cytokines and enhances antigen-specific transforming growth factor beta production in antigen-induced arthritis [PDF]

, 2013
Introduction: Interferon alpha (IFN-α) has a complex role in autoimmunity, in that it may both enhance and prevent inflammation. We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered ...
Paudyal, Bhesh Raj, Paudyal, Bhesh Raj,, Narendra, Sudeep Chenna,, Magnusson, Mattias,, Magnusson, Mattias, Chalise, Jaya Prakash,, Narendra, Sudeep Chenna, Chalise, Jaya Prakash   +7 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Novel fusion protein-expressing lentiviral vectors ameliorate collagen induced arthritis [PDF]

, 2010
Collagen induced arthritis (CIA) is a mouse model of autoimmunity that closely resembles human rheumatoid arthritis (RA), a debilitating disease with no cure.
Ward, E.M.
core  

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Gladman, D.D., GRAPPA, Fiorentino, David, Taylor, William J., de Vlam, K., Helliwell, P., Kavanaugh, Arthur, FitzGerald, Oliver, Gottlieb, A. B., Helliwell, Philip, McHugh, N.J., Gladman, Dafna D., Nash, P., Mease, P.J., Boehncke, W-H., McHugh, Neil J., Soriano, E.R., Gottlieb, Alice B., Gladman, D. D., Gottlieb, A.B., FitzGerald, O., Boehncke, Wolf-Henning, Taylor, W.J., McHugh, N. J., Ritchlin, C.T., Mease, Philip J., Mease, P. J., Nash, Peter, Soriano, Enrique R., Qureshi, A. A., Taylor, W. J., Ritchlin, Christopher T., Ritchlin, C. T., Kavanaugh, A., Qureshi, Abrar A., Qureshi, A.A., Boehncke, W. H., Fiorentino, D., Vlam, Kurt de, Soriano, E. R.   +39 more
core   +1 more source