Fms-like tyrosine kinase 3 ligand controls formation of regulatory T cells in autoimmune arthritis. [PDF]
PLoS ONE, 2013 Fms-like tyrosine kinase 3 ligand (Flt3L) is known as the primary differentiation and survival factor for dendritic cells (DCs). Furthermore, Flt3L is involved in the homeostatic feedback loop between DCs and regulatory T cell (Treg).
Mattias N D Svensson +9 more
doaj +1 more source
Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]
, 2010 Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H +23 more
core +1 more source
Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis. [PDF]
, 2007 Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias.
Strobel, S +9 more
core +2 more sources
Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. [PDF]
PLoS ONE, 2012 OBJECTIVE: Invariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer). Glucose-6-phosphate isomerase (GPI)-induced arthritis is a closer model of
Masanobu Horikoshi +8 more
doaj +1 more source
Quantitative assessment of angiogenesis in murine antigen-induced arthritis by intravital fluorescence microscopy [PDF]
, 2003 Inhibition of angiogenesis might be a therapeutic approach to prevent joint destruction caused by the overgrowing synovial tissue during chronic joint inflammation.
Schmitt-Sody, M. +7 more
core +1 more source
Antifibroproliferative effect of tenidap in chronic antigen‐induced arthritis [PDF]
Arthritis & Rheumatism, 1997 AbstractObjective. To determine whether tenidap regulates extracellular matrix metabolism in chronic arthritis.Methods. Antigen arthritis was induced in the knees of 30 rabbits. Animals were distributed into 3 groups: untreated, tenidap‐treated, and diclofenactreated rabbits.
O, Sánchez-Pernaute +7 more
openaire +2 more sources
PLoS ONE, 2014 Neurogenesis in the subgranular zone of the mammalian hippocampal dentate gyrus contributes significantly to brain neuroplasticity. There is evidence that inflammation of the central nervous system inhibits neurogenesis but peripheral inflammation such ...
Johannes Leuchtweis +4 more
doaj +1 more source
CD44 antibodies and immune thrombocytopenia in the amelioration of murine inflammatory arthritis. [PDF]
PLoS ONE, 2013 Antibodies to CD44 have been used to successfully ameliorate murine models of autoimmune disease. The most often studied disease model has been murine inflammatory arthritis, where a clear mechanism for the efficacy of CD44 antibodies has not been ...
Patrick J Mott, Alan H Lazarus
doaj +1 more source
Prevention of arthritis by interleukin 10-producing B cells [PDF]
, 2003 In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C. +7 more
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Lentivirus infection augments concurrent antigen‐induced arthritis [PDF]
Arthritis & Rheumatism, 1987 AbstractExperimental antigen–induced arthritis was compared in normal goats and goats infected with caprine arthritis‐encephalitis virus. Although acute arthritis was the same in infected and uninfected animals, the disease lasted 16 weeks longer in the caprine arthritis‐encephalitis virus–infected goats.
K L, Banks +3 more
openaire +2 more sources