Results 131 to 140 of about 3,243,106 (373)

THE LYMPH SELF ANTIGEN REPERTOIRE

Frontiers in Immunology, 2013
The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
doaj   +1 more source

Exosomes function in antigen presentation during an in vivo Mycobacterium tuberculosis infection

Scientific Reports, 2017
Mycobacterium tuberculosis-infected macrophages and dendritic cells are limited in their ability to present antigen to CD4+ T cells suggesting that other mechanism of antigen presentation are driving the robust T cell response observed during an M ...
V. L. Smith, Yong Cheng, B. Bryant, J. Schorey   +3 more
semanticscholar   +1 more source

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Antigen Presentation Profiling Reveals Recognition of Lymphoma Immunoglobulin Neoantigens

Nature, 2017
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge.
M. Khodadoust, N. Olsson, Lisa E. Wagar, O. Haabeth, Binbin Chen, Kavya Swaminathan, Keith Rawson, C. Liu, D. Steiner, P. Lund, Samhita Rao, Lichao Zhang, C. Marceau, H. Stehr, Aaron M. Newman, D. Czerwinski, V. Carlton, M. Moorhead, M. Faham, H. Kohrt, J. Carette, Michael R. Green, Mark M. Davis, Ronald Levy, Joshua E. Elias, Ash A. Alizadeh   +25 more
semanticscholar   +1 more source

Immunization and Aging: a Learning Process in the Immune Network

, 1998
The immune system can be thought as a complex network of different interacting elements. A cellular automaton, defined in shape-space, was recently shown to exhibit self-regulation and complex behavior and is, therefore, a good candidate to model the ...
A. Coutinho, A. S. Perelson, A. T. Bernardes, Américo T. Bernardes, D. Holmberg, D. Stauffer, N. Jan, N. K. Jerne, R. J. De Boer, R. M. Zorzenon dos Santos, R. M. Zorzenon dos Santos, Rita Maria Zorzenon dos Santos, W. M. Lahmann   +12 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation [PDF]

, 2017
Shin-Rong Wu, Yashar S. Niknafs, Stephanie H. Kim, Katherine Oravecz-Wilson, Cynthia Zajac, Tomomi Toubai, Yaping Sun, Jayendra Prasad, Daniel Peltier, Hideaki Fujiwara, Israel Hedig, Nathan D. Mathewson, Rami Khoriaty, David Ginsburg, Pavan Reddy   +14 more
openalex   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source