Results 91 to 100 of about 63,337 (255)

Publisher Correction: Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. [PDF]

Nat Commun, 2023
Meier CS, Pagni M, Richard S, Mühlethaler K, Almeida JMGCF, Nevez G, Cushion MT, Calderón EJ, Hauser PM.   +8 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes. [PDF]

PLoS Pathog, 2023
Escrivani DO, Scheidt V, Tinti M, Faria J, Horn D.   +4 more
europepmc   +1 more source

Antigenic variation in malaria

Cell, 1995
Borst, Piet, Bitter, Wilbert, McCulloch, Richard, van Leeuwen, Fred, Rudenko, Gloria   +4 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. [PDF]

Elife, 2023
Touray AO, Rajesh R, Isebe T, Sternlieb T, Loock M, Kutova O, Cestari I.   +6 more
europepmc   +1 more source

Trypanosome sociology and antigenic variation

Parasitology, 1989
SUMMARYSurvival of the trypanosome (Trypanosoma brucei) population in the mammalian body depends upon paced stimulation of the host's humoral immune response by different antigenic variants and serial sacrifice of the dominant variant (homotype) so that minority variants (heterotypes) can continue the infection and each become a homotype in its turn ...
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

R-loops modulate Trypanosome antigenic variation.

PLoS Genetics, 2018
Lauren L Prister, H Steven Seifert
doaj   +1 more source