Results 121 to 130 of about 2,182,609 (246)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Antigenic variation in the bovine ephemeral fever virus glycoprotein [PDF]
, 1993 Antigenic variation in the bovine ephemeral fever virus glycoprotein was demonstrated using monoclonal antibodies and comparing a particular passage level of the BB7721 strain with (1) other Australian isolates of BEF virus, (2) the Beijing 1 strain of ...
St George, T. D., Cybinski, D. H.
core
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li +7 more
wiley +1 more source
Antigenic variation in Plasmodium falciparum: mechanisms and consequences.
, 1999 In the past year, the major advances in malaria antigenic variation have been concerned with the transcription and switching of variant antigen genes, and the functional expression of regions of the major variant antigen.
Chris I Newbold
core +1 more source
Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes. [PDF]
PLoS Pathog, 2023 Escrivani DO +4 more
europepmc +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Antigenic variation in Giardia lamblia: infection of congenitally athymic nude and scid mice.
, 1991 Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7).
Nash, T E +5 more
core +1 more source
PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. [PDF]
Elife, 2023 Touray AO +6 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source