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An Introduction to Antigenic Variation in Trypanosomes
The American Journal of Tropical Medicine and Hygiene, 1980The salivarian trypanosomes have a unique capacity for antigenic variation at the cell surface. This phenomenon is their primary mechanism for evasion of the host's immune response. Variation is mediated through alternate expression of an extensive repertoire of variant surface glycoproteins (VSGs).
G A, Cross +3 more
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Phase variation and antigenic variation
2005A review on the best understood mechanisms of phenotypic diversification by phase variation and antigenic variation, and their functions. Topics discussed include DNA inversion, gene conversion, phase variation by slipped-strand mispairing, phase variation by an epigenetic mechanism, influence of environmental conditions on phase variation, and phase ...
Villemur, Richard, Déziel, Éric
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Antigenic variation in visna virus
Cell, 1979Two antigenic variants of visna virus were isolated sequentially from a single sheep inoculated with a plaque-purified strain of virus designated 1514. The genetically stable variants, LV1-1 and LV1-4, are of two classes: LV1-1 is partially neutralized by antibody to the inoculum strain 1514, while LV1-4 is not neutralized by antibody to 1514.
J V, Scott +4 more
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Unstable antigenic variation of leptospiras
Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale. A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie, 1981The antigenic variants which were found in leptospiras, Leptospira interrogans serovar copenhageni Shibaura grown in a liquid medium containing a homologous antiserum were found to be unstable. The unstable variants showed decreased agglutinability against the homologous antiserum.
E, Shimono, R, Yanagawa
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Antigenic Variation in Plasmodium falciparum
2015Plasmodium falciparum is the protozoan parasite that causes most malaria-associated morbidity and mortality in humans with over 500,000 deaths annually. The disease symptoms are associated with repeated cycles of invasion and asexual multiplication inside red blood cells of the parasite. Partial, non-sterile immunity to P.
Michaela, Petter, Michael F, Duffy
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Molecular genetics of antigenic variation
Immunology Today, 1991Antigenic variation is one of the most effective strategies developed by parasites to escape immune destruction. It requires a large wardrobe of surface coats and mechanisms to exchange one coat for an unrelated one. The molecular principles of antigenic variation are now largely known in the bacterial species Borrelia and Neisseria and in the protozoa
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Antigenic variation in malaria parasites
Immunology Today, 1985Antigenic variation and sequestration in organ capillary systems are two of the ways by which malaria parasites escape immune effector mechanisms. Here Marcel Hommel discusses the presence of variant antigens and endothelial-binding molecules on the surface of infected erythrocytes in the context of malaria immunity.
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Antigenic Variation in the Salivarian Trypanosomes
1977The term “antigenic variation” has been widely used to describe a phenomenon in which, during infection of the final host by what is taxonomically considered a single species of pathogenic protozoa, there arises a succession of parasite populations, each recognized as antigenically different by the host’s immune response.
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