Results 51 to 60 of about 1,199,934 (306)

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
Davey Martin S., Toleman Mark A., Davey, Martin S, Parish, T., Simon J. Davies, Gareth W Roberts, Williams, John David, Parish, T, Johnson, David W, John D Williams, David W Johnson, Davies, S. J., Tanya Parish, Brown, A. C., James A Chess, Chess, James Anthony, Johnson, D. W., Gareth W. Roberts, Lin Chan-Yu, Martin S. Davey, Heuston, Sinead, Toleman, Mark A., Heuston Sinéad, Cormac G. M. Gahan, Amanda C Brown, Martin S Davey, Johnson, David Westley, Roberts Gareth W., Gahan Cormac G. M., Davey, MS, Eberl, M, Gahan, C. G. M., Parish, Tanya, Chess, James A, Davies, Simon J, Hill, C., Moser Bernhard, Gahan, Cormac G M, James A. Chess, Williams, John D., Amanda C. Brown, Heuston, S., Brown, Amanda C., Moser, B, Brown, Amanda C, Davey, Martin S., Roberts, Gareth W., Johnson, David W., Toleman, MA, Toleman, Mark A, Davies Simon J., Gahan, CGM, David W. Johnson, Topley, N, Williams, John D, Bernhard Moser, Parish Tanya, Gahan, Cormac G., Topley Nicholas, Chess, JA, Moser, Bernhard, Williams, JD, Heuston, S, Johnson David W., Chess, James A., Gahan, Cormac G. M., Simon J Davies, Topley, Nicholas, Brown, AC, Hill Colin, Hill, C, Eberl, Matthias, Brown Amanda C., Davies, SJ, Mark A. Toleman, Cormac G M Gahan, Eberl Matthias, Mark A Toleman, Nicholas Topley, Hill, Colin, Chan-Yu Lin, Colin Hill, Toleman, Mark Alexander Howard, Roberts, GW, Lin, CY, Johnson, DW, Chess James A., Lin, Chan-Yu, Williams John D., Davies, Simon J., John D. Williams, Sinéad Heuston, Roberts, Gareth W, Matthias Eberl   +93 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Antibody-guided identification of Achromobacter xylosoxidans protein antigens in cystic fibrosis

mSphere
Persistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these ...
Cecilia Sahl, Sounak Chowdhury, Johan Malmström, Lisa I. Påhlman   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immunologic and clinical features of bacterial uveitis

Российский офтальмологический журнал
Bacterial infection is one of the etiologic factors of inflammation of the uvea. Bacterial agents capable of provoking the development of uveitis are numerous and diverse (Gram-positive and Gram-negative; bacilli, cocci, and flagellates; aerobic and ...
E. A. Kleshcheva, S. A. Kochergin, G. Sh. Arzhimatova, A. E. Kleshchev, N. V. Mel'nikova, E. V. Shirshova   +5 more
doaj   +1 more source

Crossroads between bacterial and mammalian glycosyltransferases

Frontiers in Immunology, 2014
Bacterial glycosyltransferases often synthesize the same glycan linkages as mammalian glycosyltransferases, yet they usually have very little sequence identity.
Inka eBrockhausen
doaj   +1 more source

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]

, 2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco, Locatelli, Franco, Giulia Casorati, Paul Jenö, Chengfeng Xia, Consonni, Michela, S. R. Gundimeda, P. Jeno, Daniela Montagna, C. Bonini, Alessandra Forcina, G. Casorati, Claudia de Lalla, Franco Locatelli, Sansano, Sebastiano, Bonini, Chiara, Piccolo, Francesco, Xia, Chengfeng, Z. Li, P. Dellabona, Garavaglia, Claudio, H. Gsellinger, F. Piccolo, de Lalla, Claudia, Paolo Dellabona, G. Ni, F. Ciceri, Gundimeda, S. Ramanjaneyulu, Heiko Gsellinger, Häussinger, Daniel, Daniel Häussinger, Scelfo, Andrea, L. Mori, C. Garavaglia, Gennaro De Libero, A. Bondanza, Michela Consonni, Sebastiano Sansano, A. Forcina, Ciceri, Fabio, Jenö, Paul, Fabio Ciceri, M. Lepore, Attilio Bondanza, Gsellinger, Heiko, De Libero, Gennaro, S. Sansano, Bondanza, Attilio, Casorati, Giulia, D. Haussinger, Marco Lepore, C. de Lalla, G. De Libero, M. Consonni, Guanghui Ni, Lucia Mori, Li, Zhiyuan, Zhiyuan Li, Montagna, Daniela, Forcina, Alessandra, Andrea Scelfo, Mori, Lucia, S. Ramanjaneyulu Gundimeda, Chiara Bonini, Claudio Garavaglia, A. Scelfo, Francesco Piccolo, Ni, Guanghui, C. Xia, Dellabona, Paolo   +69 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Inter-individual and inter-regional variability of breast milk antibody reactivity to bacterial lipopolysaccharides

Frontiers in Immunology
Breast milk is a vital source of nutrients, prebiotics, probiotics, and protective factors, including antibodies, immune cells and antimicrobial proteins. Using bacterial lipopolysaccharide arrays, we investigated the reactivity and specificity of breast
Lisa Crone, Jens Sobek, Nicole Müller, Tanja Restin, Tanja Restin, Dirk Bassler, Daniela Paganini, Michael B. Zimmermann, Patricia Zarnovican, Françoise H. Routier, Tais Romero-Uruñuela, Luis Izquierdo, Luis Izquierdo, Thierry Hennet   +13 more
doaj   +1 more source

Parasite Carbohydrate Vaccines

Frontiers in Cellular and Infection Microbiology, 2017
Vaccination is an efficient means of combating infectious disease burden globally. However, routine vaccines for the world's major human parasitic diseases do not yet exist. Vaccines based on carbohydrate antigens are a viable option for parasite vaccine
Jonnel A. Jaurigue, Jonnel A. Jaurigue, Peter H. Seeberger, Peter H. Seeberger   +3 more
doaj   +1 more source