Results 41 to 50 of about 194,746 (267)

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Human colon stem cells are the predominant epithelial responders to bacterial antigens

Frontiers in Immunology
Intestinal epithelial cells (IECs) are capable of mounting an adequate antimicrobial inflammatory response to pathogens while tolerating commensals. The underlying regulatory mechanisms of immune sensitivity remain incompletely understood, particularly ...
Maaike H. De Vries, Maaike H. De Vries, Claartje A. Meddens, Claartje A. Meddens, Hemme J. Hijma, Hemme J. Hijma, Anne-Claire Berrens, Anne-Claire Berrens, Suze A. Jansen, Suze A. Jansen, Berend A. P. Kooiman, Berend A. P. Kooiman, Scott Snapper, Hans Clevers, Hans Clevers, Hans Clevers, Michal Mokry, Michal Mokry, Michal Mokry, Michal Mokry, Ewart W. Kuijk, Ewart W. Kuijk, Ewart W. Kuijk, Edward E. S. Nieuwenhuis, Edward E. S. Nieuwenhuis   +24 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Assessment of clinical state of the palatine tonsils of patients with chronic tonsillitis after immynotherapy in the form of vaccination with bacterial antigens

Acta Medica Leopoliensia, 2018
Aim. Determine the effect of mucosal vaccination on changes in the clinical status of patients with chronic tonsillitis. Materials and Metods. In these clinical studies, 92 patients aged 18 to 40 years participated.
O.I. Tynitovska
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

House dust mites as potential carriers for IgE sensitization to bacterial antigens

Revista Alergia México, 2018
Background: IgE-reactivity to antigens from gram-positive and negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitisation are not fully understood.
Sheron Dzoro, Irene Mittermann, Yvonne Resch, Susanne Vrtala, Marion Nehr, Alexander M. Hirschl, Gustav Wikberg, Lena Lundeberg, Catharina Johansson, Annika Scheynius, Rudolf Valenta   +10 more
doaj  

EFFECTIVENESS OF A TEST-SVSTEM FOR DIAGNOSTICS OF MELIOIDOSIS AND GLANDERS BASED ON PASSIVE HEMAGGLUTINATION REACTION AND SOLID-PHASE ENZYME IMMUNOASSAY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Analysis of published results of studies of effect of various antigens of Burkholderia pseudomallei and B. mallei on operation characteristics (sensitivity and specificity) of tests for diagnostics of melioidosis and glanders based on reaction of passive
A. A. Budchenko
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

FEATURES OF IMMUNE RESPONSE DURING VARIOUS SCHEMES OF USE OF BACTERIAL THERAPEUTIC VACCINE IMMUNOVAC VP-4

Журнал микробиологии, эпидемиологии и иммунобиологии, 2017
Aim. Study the dynamics of immunologic parameters in patients with chronic bacterial infections during various schemes of administration of Immunovac VP-4 vaccine. Materials and methods.
L. I. Krasnoproshina, T. A. Serova, E. P. Foshina, I. V. Bisheva, S. A. Skhodova   +4 more
doaj   +1 more source

Salmonella modulates B cell biology to evade CD8+ T cell-mediated immune responses

Frontiers in Immunology, 2014
Although B cells and antibodies are the central effectors of humoral immunity, B cells can also produce and secrete cytokines and present antigen to helper T cells.
Marcela eLopez-Medina, Araceli ePerez-Lopez, Araceli ePerez-Lopez, Celia eAlpuche-Aranda, Vianney eOrtiz-Navarrete   +4 more
doaj   +1 more source