Results 71 to 80 of about 320,891 (294)

Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens

Cell Reports Medicine
Summary: Therapeutic antibodies are actively explored as alternative to treat or prevent bacterial infections. However, the narrow antigen specificity of IgG in combination with broad diversity in bacterial surface structures currently hampers the ...
Remy M. Muts, Astrid Hendriks, Josefien W. Hommes, Max L.B. Grönloh, Douwe J. Dijkstra, Carla J.C. de Haas, Piet C. Aerts, Eduard H.T.M. Ebberink, Albert J.R. Heck, Zhen Wang, Haoru Zhuang, Jeroen D.C. Codée, Bas G.J. Surewaard, Dani A.C. Heesterbeek, Nina M. van Sorge, Suzan H.M. Rooijakkers   +15 more
doaj   +1 more source

IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates

mBio, 2018
Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease.
Anna E. Schager, C. Coral Dominguez-Medina, Francesca Necchi, Francesca Micoli, Yun Shan Goh, Margaret Goodall, Adriana Flores-Langarica, Saeeda Bobat, Charlotte N. L. Cook, Melissa Arcuri, Arianna Marini, Lloyd D. W. King, Faye C. Morris, Graham Anderson, Kai-Michael Toellner, Ian R. Henderson, Constantino López-Macías, Calman A. MacLennan, Adam F. Cunningham   +18 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Assessment of clinical state of the palatine tonsils of patients with chronic tonsillitis after immynotherapy in the form of vaccination with bacterial antigens

Acta Medica Leopoliensia, 2018
Aim. Determine the effect of mucosal vaccination on changes in the clinical status of patients with chronic tonsillitis. Materials and Metods. In these clinical studies, 92 patients aged 18 to 40 years participated.
O.I. Tynitovska
doaj   +1 more source

Variable protection against experimental broiler necrotic enteritis after immunisation with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant [PDF]

, 2016
Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis (NE), a disease causing significant costs to the poultry production industry worldwide.
Bokori-Brown, Monika, Fernandes da Costa, Sergio, Geeraerts, Sofie, Mot, Dorien, Titball, Richard, Van Immerseel, Filip   +5 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

House dust mites as potential carriers for IgE sensitization to bacterial antigens

Revista Alergia México, 2018
Background: IgE-reactivity to antigens from gram-positive and negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitisation are not fully understood.
Sheron Dzoro, Irene Mittermann, Yvonne Resch, Susanne Vrtala, Marion Nehr, Alexander M. Hirschl, Gustav Wikberg, Lena Lundeberg, Catharina Johansson, Annika Scheynius, Rudolf Valenta   +10 more
doaj  

EFFECTIVENESS OF A TEST-SVSTEM FOR DIAGNOSTICS OF MELIOIDOSIS AND GLANDERS BASED ON PASSIVE HEMAGGLUTINATION REACTION AND SOLID-PHASE ENZYME IMMUNOASSAY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Analysis of published results of studies of effect of various antigens of Burkholderia pseudomallei and B. mallei on operation characteristics (sensitivity and specificity) of tests for diagnostics of melioidosis and glanders based on reaction of passive
A. A. Budchenko
doaj   +1 more source

Lipopolysaccharide (LPS, endotoxin) of Proteus bacteria-chemical structure, serological specificity and the role in pathogenicity [PDF]

, 2008
Lipopolysaccharides (LPS) of Gram-negative bacteria are composed of three regions: О-specific chain (OPS), the core oligosaccharide and lipid A. All three regions of Proteus LPS were studied. The differences in the structure of OPS serve as the basis
Różalski, Antoni
core