Results 181 to 190 of about 830,599 (290)

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Atopic Dermatitis and Celiac Disease: A Study of US Adults in the NIH All of US Research Program. [PDF]

Int J Dermatol
Craver AE, Damsky W, Cohen JM.
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Imbalanced IgA-IgG class switching recombination: a novel mechanism of gut immune dysregulation in inflammatory bowel disease. [PDF]

Front Immunol
Chen K, Qing Y, Gao W, Feng W, Tian J, Wang J.   +5 more
europepmc   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Extending Small‐Molecule Aptamer Discovery Principles to Protein Targets: Selection and Characterization of Green Fluorescent Protein Aptamers

Angewandte Chemie, EarlyView.
Protein‐binding aptamers remain poorly understood compared to their small‐molecule counterparts. Using green fluorescent protein (GFP) variants as a tractable model system, we show how subtle changes in protein surface composition and divalent metal ions reshape aptamer selection, specificity, and binding.
Stefen Stangherlin, Nathan Wong, Logan Fanning, Kate Kim, Peter Kim, Iffat Tabassum, Songyang Miao, Rui Huang, Juewen Liu   +8 more
wiley   +2 more sources

Comprehensive Phenotyping of Circulating T- and B-Cell Subsets in Patients with Ankylosing Spondylitis Associated with Crohn's Disease. [PDF]

Cells
Rubinstein A, Aquino A, Davydov D, Shchukina O, Korobova Z, Mammedova J, Starikova E, Marchenko V, Galagudza M, Kudryavtsev I.   +9 more
europepmc   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji   +4 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis. [PDF]

JCI Insight
Chan JE, Mohsin A, Krijgsman J, Lindelauf C, Mu Q, Cavalla B, Ji X, Streett SE, van Unen V, Davis MM.   +9 more
europepmc   +1 more source