Results 71 to 80 of about 156,759 (312)

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Do postoperative infectious complications really affect long‐term survival in colorectal cancer surgery? A multicenter retrospective cohort study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 110-120, January 2023., 2023
This multicenter retrospective cohort study suggested that postoperative infection (PI) after curative colorectal surgery (CRC) is associated with impaired oncological outcomes. Strategies to prevent PI and implement appropriate postoperative treatment may improve the quality of care and oncological outcomes in patients undergoing curative CRC surgery.
Akihisa Matsuda, Hiroshi Maruyama, Shinji Akagi, Toru Inoue, Kenichiro Uemura, Minako Kobayashi, Hisanori Shiomi, Manabu Watanabe, Hiroki Arai, Yutaka Kojima, Yusuke Mizuuchi, Hajime Yokomizo, Yuji Toiyama, Toru Miyake, Yasuyuki Yokoyama, Kei Ishimaru, Shigeru Takeda, Yoshihisa Yaguchi, Yuko Kitagawa   +18 more
wiley   +1 more source

Development of an Electrochemical Immunosensor for Specific Detection of Visceral Leishmaniasis Using Gold-Modified Screen-Printed Carbon Electrodes

Biosensors, 2020
Visceral leishmaniasis is a reemerging neglected tropical disease with limitations for its diagnosis, including low concentration of antibodies in the serum of asymptomatic patients and cross-reactions.
Beatriz R. Martins, Yanne O. Barbosa, Cristhianne M. R. Andrade, Loren Q. Pereira, Guilherme F. Simão, Carlo J. de Oliveira, Dalmo Correia, Robson T. S. Oliveira, Marcos V. da Silva, Anielle C. A. Silva, Noelio O. Dantas, Virmondes Rodrigues, Rodrigo A. A. Muñoz, Renata P. Alves-Balvedi   +13 more
doaj   +1 more source

Computational model for tumor response to adoptive cell transfer therapy [PDF]

arXiv, 2022
One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv  

Malaria vaccines 1985-2005: a full circle?

, 2005
Few who were actively engaged in malaria vaccine research 20 years ago (including myself) would have imagined that, in 2005, there would still be a prediction of a 10-20-year horizon before vaccines become part of malaria-control strategies.
Targett, Geoffrey A
core   +1 more source

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
A Boëdec, A Matsushima, A Reichenberg, AC Brown, AC Hayday, AC Hayday, Amanda C. Brown, B Altincicek, B Moser, Bernhard Moser, C Agrati, C Belmant, C De Santo, C Münz, CC Szeto, Chan-Yu Lin, CM Bunke, Colin Hill, Cormac G. M. Gahan, CT Morita, CT Spencer, CT Weaver, D Vermijlen, David W. Johnson, DI Godfrey, DJ Pennington, DK Kim, E Oldfield, E. John Wherry, F Annunziato, F Dieli, F Sallusto, G Sarikonda, Gareth W. Roberts, GW Roberts, H Jomaa, H Jomaa, H Li, H Wang, H Wei, I Müller, J Feurle, J Mookerjee-Basu, James A. Chess, JF Bukowski, JJ O'Shea, John D. Williams, JS Savill, K Pietschmann, KJ Puan, KK Kumarasamy, KM Murphy, L Troidle, M Begley, M Begley, M Blunden, M Bonneville, M Brandes, M Eberl, M Eberl, M Eberl, M Eberl, M Eberl, M Fahim, M Kistowska, M Krishnan, M Pelletier, M Rohmer, MA Missinou, Mark A. Toleman, Martin S. Davey, Matthias Eberl, MC Devilder, MC Devilder, MI Hirsh, MJ Llewelyn, N Nathan, N Topley, Nicholas Topley, O Devuyst, P Choi, P Constant, PS Evans, R Medzhitov, RE Rojas, RM McLoughlin, S Amslinger, S Mujais, Simon J. Davies, Sinéad Heuston, SJ Davies, SM Hurst, SR Gill, T Ganz, Tanya Parish, TR Walsh, TW Rice, W Holtmeier, Y Kato, Y Neu, Y Tanaka, Y Zhang   +101 more
core   +4 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Sequence-Based Nanobody-Antigen Binding Prediction [PDF]

arXiv, 2023
Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production.
arxiv  

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics

Aggregate, Volume 3, Issue 6, December 2022., 2022
The aggregation‐induced emission luminogens (AIEgens) propel the development of drug and gene delivery systems. The lit‐up AIEgens first serve for real‐time monitoring of the delivery processes and evaluation of therapeutic responses of drug/gene. The delicate design of AIEgens to form high‐level structural carrier remarkably enhances the delivery ...
Jie Sun, Xuewen He
wiley   +1 more source