Results 51 to 60 of about 77,146 (282)

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine [PDF]

, 2018
Dietary antigens are normally rendered nonimmunogenic through a poorly understood "oral tolerance" mechanism that involves immunosuppressive regulatory T (T-reg) cells, especially Treg cells induced from conventional T cells in the periphery (pT(reg ...
Yang, BG, Jung, J, Bo-Gie Yang, Charles D. Surh, Hong, SW, Sung-Wook Hong, Minji Lee, Lee, MJ, Yi, J, Jisun Jung, Kwang Soon Kim, Jaeu Yi, Daehee Han, Lee, JY, Surh, CD, Han, D, Jun Young Lee, Kim, KS   +17 more
core   +1 more source

A Characterization of the Humoral Immune Response to Human Endogenous Retroviruses and Mycobacterium paratuberculosis in Crohn’s Disease

Pathogens
Crohn’s disease (CD) is a multifactorial polygenic inflammatory bowel disease linked to aberrant immune response. Mycobacterium paratuberculosis (MAP) has been associated with CD; however, detecting MAP in CD tissues remains highly challenging. Recently,
Alishba Fayyaz, Luigi Cugia, Marta Noli, Somaye Jasemi, Elena Rita Simula, Leonardo A. Sechi   +5 more
doaj   +1 more source

Loss and Gain of Tolerance to Pancreatic Glycoprotein 2 in Celiac Disease.

PLoS ONE, 2015
BackgroundAutoantibodies against pancreatic secretory-granule membrane glycoprotein 2 (GP2) have been demonstrated in patients with Crohn's disease but recently also with celiac disease (CD).
Martin W Laass, Nadja Röber, Ursula Range, Lydia Noß, Dirk Roggenbuck, Karsten Conrad   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Expression of CD-95 and CD-95L in DCs expressing F or core protein. [PDF]

, 2014
DCs were infected with adenovirus containing HCV-derived F and core antigens. After 48 hours of infection, DCs were harvested and stained with antibodies against CD-95L (A, left panel) and CD-95 (A, right panel).
Shakti Singh (515117), Subodh Kumar Samrat (515116), Babita Agrawal (241460), Rakesh Kumar (8432), Wen Li (143214)   +4 more
core   +1 more source

CD Antigens 2001: Aims and Results of HLDA Workshops [PDF]

Stem Cells, 2001
aThe Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom; bCentre d'Immunologie, Parc Scientifique de Luminy, Cedex, France; cFaculte de Medicine de Creteil, Cedex, France; dDivision of Immunity and Infection, MRC Center for Immune Regulation, Department of Rheumatology, University of Birmingham, Edgbaston,
D, Mason, P, André, A, Bensussan, C, Buckley, C, Civin, E, Clark, M, de Haas, S, Goyert, M, Hadam, D, Hart, V, Horejsí, S, Meuer, J, Morrissey, R, Schwartz-Albiez, S, Shaw, D, Simmons, M, Uguccioni, E, van der Schoot, E, Vivier, H, Zola   +19 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity [PDF]

, 2011
<p><b>Background:</b> Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer).
Taracha, E. L. N., Mwangi Duncan M., Graham Simon P., Paul R. Spooner, Graham, S. P., Saya, RM, Toye, PG, Njahira, Moses N., Pelle, R., Richard P Bishop, Musoke, AJ, Silva, J., Rosemary M. Saya, Philip G Toye, Toye Philip G., Njahira, M.N., Saya, R. A., Evans L. N. Taracha, Musoke, A. J., Pelle Roger, Odongo, DO, Silva Joana C., Roger Pelle, Musoke Anthony J., Morrison, Ivan, Weir, W., Silva, J.C., Anthony J. Musoke, Joana C Silva, Graham, SP, Bishop, Richard P., Odongo, David O., Simon P Graham, Paul R Spooner, Taracha, EL, Morrison W. Ivan, Pelle, R, Bishop, R.P., Toye, P. G., Moses N Njahira, Saya Rosemary M., Duncan M. Mwangi, Spooner, P.R., Osaso Julius, Mwangi, D.M., W. Ivan Morrison, Toye, P.G., Silva, J. C., David O. Odongo, Osaso, J, Morrison, WI, Simon P. Graham, Moses N. Njahira, Mwangi, D. M., Evans L N Taracha, Taracha Evans L. N., Mwangi, DM, Odongo, D.O., Taracha, E.L.N., Bishop, RP, Morrison, W.I., Bishop, R. P., Njahira, M. N., Saya, R.M., Spooner, PR, Musoke, A.J., Saya, Rosemary M., Spooner, P. R., Richard P. Bishop, Pelle, Roger, Mwangi, David Miano, Spooner Paul R., Rosemary M Saya, Odongo David O., Njahira, MN, Joana C. Silva, Odongo, D. O., Duncan M Mwangi, Julius Osaso, W Ivan Morrison, Toye, Philip G., Njahira Moses N., Philip G. Toye, Morrison, W. Ivan, David O Odongo, Weir William, Bishop Richard P., Silva, JC, Osaso, J., Anthony J Musoke, Graham, S.P., William Weir, Weir, W   +92 more
core   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source