Results 161 to 170 of about 252,541 (298)

Adoptive T Cell therapy for cancer and autoimmune disease: current advances, challenges, and future directions. [PDF]

Oncol Rev
Bao QH, Wu A, Pang J, Wang J, Chen Q, Wu S.   +5 more
europepmc   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases. [PDF]

Signal Transduct Target Ther
Fan Z, Zheng X, Jin C, Zhang J, Gong N, Li X.   +5 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Chimeric antigen receptor T cell therapy in autoimmune neurological disease: current status of efficacy and safety. [PDF]

BMJ Neurol Open
Bradhurst P, Hardy TA, Riminton S.
europepmc   +1 more source

Angiogenesis‐associated immune genes as prognostic markers and predictors of immunotherapy response in pancreatic ductal adenocarcinoma

VIEW, EarlyView.
Pancreatic ductal adenocarcinoma exhibits marked angiogenic and immune heterogeneity. We identified 28 angiogenesis‐associated immune genes and developed a seven‐gene AIGScore model comprising FGF2, ADGRB3, MMP2, TYMP, VASH1, VEGFD, and ITGAV. A high AIGScore was associated with poor survival, an immunosuppressive tumor microenvironment, and reduced ...
Qing Chang, Qian Wang, Xiumei Jiang, Yongmei Yang, Ailin Qu   +4 more
wiley   +1 more source

Programmable CAR and antigen pairing for solid tumor immunotherapy. [PDF]

Mol Ther Oncol
Huang Z, Wang Y.
europepmc   +1 more source

Development of a Novel Anti-CD19 Chimeric Antigen Receptor

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed ...
Castellà, Maria, Boronat, Anna||, Martín-Ibáñez, Raquel, Rodríguez, Vanina, Suñé, Guillermo||, Caballero, Miguel||, Marzal, Berta, Pérez-Amill, Lorena||, Martín-Antonio, B.||, Castaño Cardoso, Julio||, Bueno, Clara||, Balagué, Olga||, González-Navarro, Europa Azucena||, Serra-Pages, Carles, Engel, Pablo||, Vilella, Ramon, Benítez Ribas, Daniel||, Ortiz-Maldonado, Valentín||, Cid, Joan||, Tabera, Jaime||, Canals, Josep M.||, Lozano, Miquel||, Baumann, Tycho||, Vilarrodona, Anna||, Trias, Esteve||, Campo, Elias||, Menéndez Bujan, Pablo||, Urbano Ispizua, Álvaro||, Yagüe, Jordi||, Pérez-Galán, Patricia||, Rives, Susana||, Delgado, Julio||, Juan, Manel||   +32 more
openaire   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Multi-antigen chimeric antigen receptor-T cell therapy for relapsed/refractory B cell lymphomas. [PDF]

Front Immunol
Pandey T, Samat D, Dahiya S, Patel SA.
europepmc   +1 more source