Results 191 to 200 of about 252,541 (298)

Cord Blood‐Derived Fibroblast Activation Protein‐Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo

Cancer Science, EarlyView.
We generated cord blood‐derived FAP‐targeted CAR NK cells and evaluated their activity against cancer‐associated fibroblasts. These cells showed antigen‐specific cytotoxicity in vitro and robust persistence in a pleural dissemination model, although in vivo anti‐CAF efficacy was limited, supporting further development of stromal‐targeted cellular ...
Takashi Hiroshima, Toru Kimura, Mariko Maekawa, Mayuko Noguchi, Takahiro Matsui, Shunya Ikeda, Makiko Suga, Hideki Nagata, Kenji Kimura, Eriko Fukui, Takashi Kanou, Naoko Ose, Eiichi Morii, Yasushi Shintani, Naoki Hosen   +14 more
wiley   +1 more source

BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity. [PDF]

Immunol Rev
Luff DH, Schweighoffer E, Tybulewicz VLJ.   +2 more
europepmc   +1 more source

Evolution of CAR‐T Therapy: Functional Engineering, Manufacturing Innovation, and Future In Vivo Strategies

Cancer Science, EarlyView.
CAR‐T therapy is evolving across four interconnected dimensions: functional engineering, manufacturing innovation, alternative cell sources, and in vivo CAR programming. Together, these advances address limitations in therapeutic efficacy, safety, manufacturing complexity, scalability, and accessibility, providing complementary paths toward the next ...
Yukimi Sakoda
wiley   +1 more source

BTK Inhibitor Ibrutinib Reduces Bispecific Antibody‐Related CRS Without Undermining the Anti‐Tumor Efficacy

Cancer Science, EarlyView.
BTK inhibition reprograms macrophages to suppress IL‐6/IL‐8/IL‐10‐driven CRS without compromising BsAb efficacy. ABSTRACT Bispecific antibodies (BsAbs) have shown marked efficacy in relapsed or refractory (R/R) B‐cell non‐Hodgkin lymphoma (B‐NHL). However, their clinical utility is constrained by cytokine release syndrome (CRS).
Jiaowu Cao, Dingyao Hu, Jie Lv, Jin Chai, Yue Wang, Jie Chen, Xiaoqiang Yan, Jun Zhu, Hui Yu   +8 more
wiley   +1 more source

Chimeric antigen receptor T-cell therapy for rheumatic diseases: from B-cell depletion to immune reset and beyond. [PDF]

Front Immunol
Zhan Y, Hu C, Xiao K.
europepmc   +1 more source

Emerging Immune Cell Biomarkers in Primary Membranous Nephropathy: Immune Cell Profiling During Anti-CD20 B Cell-Targeted Therapy. [PDF]

Int J Mol Sci
Georgopoulos C, Stamellou E, Duni A, Dova L, Vartholomatos G, Siomou E, Milionis H, Dounousi E.   +7 more
europepmc   +1 more source

Peanut‐Specific IgG4 mAbs Promote Regulatory Immune Responses Ex Vivo and Improve Oral Immunotherapy in Mice

Clinical &Experimental Allergy, EarlyView.
Allergen‐specific IgG4 mAbs were shown to block facilitated IgE binding to B cells and redirect allergens towards myeloid APC, leading to increased IL‐10 production in vitro. In combination with oral AIT, the mAbs inhibited mast cell activation and sustained allergen‐specific IgG4 levels in an in vivo model of peanut allergy. ABSTRACT Background Peanut
Pascal Gasser, Alex A. J. Overman, Mojtaba Porbahaie, Chiara Arena, Juliane Konrad, Renate Repke, Sandra Götschi, Dimitri Bieli, Tiziana Sonati, Alcide Barberis, Niccolò Pengo, R. J. Joost van Neerven, Natascha Wuillemin   +12 more
wiley   +1 more source

Resistance mechanisms and overcoming strategies for CAR T-cell therapy in B-cell hematologic malignancies. [PDF]

Front Immunol
Li P, Xue X, Zhang Z.
europepmc   +1 more source

Flow cytometric identification of plasmacytoid dendritic cells in acute myeloid leukaemia: Challenges and practical considerations

British Journal of Haematology, EarlyView.
Mariana S. Vieira, Pietro B. Belmonte, Natália A. Marcondes, Raquel Q. Vidal, Flavo B. Fernandes, Liane N. Rotta   +5 more
wiley   +1 more source

Aberrant Expression of Multiple T‐Cell Markers in Primary Cutaneous Follicle Center Lymphoma: A Rare Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Aberrant expression of T‐cell markers in B‐cell lymphomas is rare and can pose diagnostic challenges. We report a case of a 65‐year‐old man presenting with newly developed scalp nodules. Histopathology revealed nodular lymphoid infiltrates composed of large centrocytes and centroblasts.
V. Pfefferle, A. Vogelsberg, M. Maaß, C. M. Schürch, S. Forchhammer   +4 more
wiley   +1 more source