Results 231 to 240 of about 252,541 (298)

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

CAR T cells against the B cell receptor to precisely eliminate pathogenic B cells. [PDF]

Mol Ther Oncol
Bochi-Layec AC, Cohen IJ, Lemoine J, Ruella M.   +3 more
europepmc   +1 more source

Preserved B Cell Function in CD23‐Cre Transgenic Mice Allows Reliable Flox‐Only Controls in Mouse Models

Immunology, EarlyView.
Expression of CD23‐Cre does not impair the function of mature B cells or the establishment of the humoral immune response. Therefore, Flox‐only mice are suitable controls in studies using a CD23‐Cre mouse model. This reduces the number of surplus animals generated and supports the 3Rs principle in animal research.
Leonie Steinmetzer, Franziska Rost, Christina B. Brunner, Daniel Ehrenschwender, Theresa Lauterbach, Theresa E. H. Bierling, Chiara Vlad, Michèle Ohnemüller, Hannah Elaine Smid, Daniel Hosp, Dirk Mielenz, Wolfgang Schuh, Katharina Pracht   +12 more
wiley   +1 more source

Multi-dimensional orchestration of binders for improved CAR-T immunotherapy. [PDF]

Cancer Lett
Zhu C, Jiang Z, Jing R, Guo W, Lu Y.
europepmc   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source

Progress and promise of CAR-T cell treatment in autoimmune diseases. [PDF]

PLoS Med
Bachl J, Hagen M, Schett G.
europepmc   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

A Novel Sulfatide Analog Recognized by Human iNKT Cells Enhances Polyfunctional Antigen-Specific CD8⁺ T Cell Responses. [PDF]

Eur J Immunol
Hara A, DiSapio J, Coombs M, Keretsu S, Korinfskaya S, Khayrullina G, Joshi V, Alam MM, Kim H, Malik N, Steffke EE, Latifi L, Hancock JC, Spurgeon JD, Ozer BH, Gilbert MR, Howell AR, Terabe M.   +17 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment. [PDF]

Biol Cell
Charrier A, Salama A, Dubreil L, Mignot G, Bosch S.   +4 more
europepmc   +1 more source