Results 31 to 40 of about 252,541 (298)
Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis
Frontiers in Immunology, 2023 IntroductionControlling pulmonary Mycobacterium avium complex (MAC) disease is difficult because there is no way to know the clinical stage accurately. There have been few attempts to use cell-mediated immunity for diagnosing the stage.
Yoshiro Yamashita +16 more
doaj +1 more source
Immunotherapeutic potential of blinatumomab-secreting γ9δ2 T Cells
Translational Oncology, 2023 Previous studies have explored the use of engineered blinatumomab-secreting autologous αβ T cells for CD19-targeted cancer therapy. To create a more flexible allogeneic delivery system, we utilized γ9δ2 T cells rather than αβ T cells in a similar ...
Shang-Ju Wu +3 more
doaj +1 more source
Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor [PDF]
Journal of Immunotherapy, 2009 T cells can be engineered to express the genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. We constructed and compared 2 CARs that contained a single chain variable region moiety that recognized CD19. One CAR contained the signaling moiety of the 4-1BB molecule and the other did not.
James N, Kochenderfer +7 more
openaire +2 more sources
Hematology/Oncology and Stem Cell Therapy, 2013 BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo +7 more
doaj +1 more source
BLDE University Journal of Health Sciences, 2022 BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease as it affects multiple lineages of hematopoietic cells. AIMS AND OBJECTIVES: This study aims to (1) evaluate the immunophenotypic findings of AML patients, (2) correlate the ...
Mekhala Rao +3 more
doaj +1 more source
Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction [PDF]
, 2022 B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest
Broc, Sabine
core +1 more source
Unifying heterogeneous expression data to predict targets for CAR-T cell therapy
OncoImmunology, 2021 Chimeric antigen receptor (CAR) T-cell therapy combines antigen-specific properties of monoclonal antibodies with the lytic capacity of T cells. An effective and safe CAR-T cell therapy strategy relies on identifying an antigen that has high expression ...
Patrick Schreiner +4 more
doaj +1 more source
Next-Generation CAR-T Cell Therapy: From Modular Design to Clinical Expansion. [PDF]
Exploration (Beijing)Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Bai Y +5 more
europepmc +2 more sources
T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells [PDF]
, 2016 The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19 ...
Michael C. Jensen +9 more
core +1 more source
Distinct and shared B cell responses of tuberculosis patients and their household contacts
PLoS ONE, 2022 This study was aimed at identifying the B cell responses which could distinguish between ‘latent tuberculosis infection (LTBI)’ and active TB disease. Study subjects were smear-positive TB patients (n = 54) and their disease-free household contacts (HHCs,
Komal Singh +5 more
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