Results 51 to 60 of about 75,785 (301)
Adoptive Cellular Therapy in Acute Myeloid Leukemia: Current Scope and Challenges
Hematology/Oncology and Stem Cell Therapy, 2022 Adoptive cellular therapies have revolutionized the management of hematologic malignancies, particularly lymphoma and multiple myeloma. These therapies targeting disease-specific antigens, such as CD19 in lymphoma and B cell maturation antigen in ...
Sankalp Arora +4 more
doaj +1 more source
Blood, 2021 Abstract Introduction: CD19-directed chimeric antigen receptor T (CART19) cell therapies have shown impressive clinical outcomes in CD19+ B-cell malignancies. All the FDA-approved CART19, including tisagenlecleucel, axicabtagene ciloleucel, brexucabtagene autoleucel, and lisocabtagene maraucel use an anti-CD19 single-chain variable ...
Ruchi Patel +20 more
openaire +1 more source
Biomarker Research, 2020 Background Mixed phenotype acute leukemia (MPAL) is a rare leukemia and is regarded as a high-risk entity with a poor prognosis. Induction therapy of an acute lymphoblastic leukemia type or hybrid regimen and hematopoietic stem cell transplantation has ...
Meng-Yun Li +9 more
doaj +1 more source
Journal of Immunology Research, 2021 Natural killer (NK) cells are part of the first line of defense that rapidly respond to malignant transformed cells. Chimeric antigen receptor- (CAR-) engineered NK cells, although are still at the preliminary stage, have been shown to be alternative to ...
Sudjit Luanpitpong +3 more
doaj +1 more source
Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]
, 2016 Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J. +7 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Journal of Translational MedicineBackground Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy.
Na Yang +11 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. [PDF]
, 1993 Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the crosslinking of CD3 are able to induce B cell proliferation and immunoglobulin secretion in a major ...
Kipps, TJ, Ranheim, EA
core
Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. [PDF]
, 2020 Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy.
Hardman, Clayton +8 more
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