Results 51 to 60 of about 1,436,444 (347)

Toxicities of CD19 CAR‐T cell immunotherapy

American journal of hematology/oncology, 2019
CD19‐targeted chimeric antigen receptor (CAR)‐modified T (CAR‐T) cell immunotherapy has demonstrated impressive results in B‐cell malignancies, and CAR‐T cell therapies targeting other antigens are in development for other cancers.
Alexandre V. Hirayama, C. Turtle
semanticscholar   +1 more source

Finding the Keys to the CAR: Identifying Novel Target Antigens for T Cell Redirection Immunotherapies

International Journal of Molecular Sciences, 2020
Oncology immunotherapy has been a significant advancement in cancer treatment and involves harnessing and redirecting a patient’s immune response towards their own tumour.
R. Abbott, R. Cross, M. Jenkins
semanticscholar   +1 more source

Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4 [PDF]

, 2010
Schistosoma haematobium antigen recognition profiles of the human isotypes IgA, IgE, IgG1 and IgG4 were compared by image analysis of western blots. Adult worm antigens separated by 2-dimensional gel electrophoresis were probed with pooled sera from ...
Midzi, N., Maizels, R M, Burchmore, R., Y. HARCUS, Mduluza, T., R. M. MAIZELS, Harcus, Y, Turner, C.M.R., R. BURCHMORE, C. M. TURNER, Mutapi, F, Midzi, N, Mutapi, F., Maizels, R.M., Turner, C M, Maizels, RM, N. MIDZI, Harcus, Y., Bourke, C., F. MUTAPI, T. MDULUZA, Turner, CM, Maizels, R. M., Bourke, C, Turner, C. M., Mduluza, T, Burchmore, R.J.S., Burchmore, R, C. BOURKE   +28 more
core   +1 more source

Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates [PDF]

, 2023
Antibody-drug conjugates consist of potent small molecule payloads linked to a targeting antibody. Payloads must possess a viable functional group by which a linker for conjugation can be attached.
Axel, Hernandez, Jr., Martin, Hayes, Michael, McPherson, Agnieszka, Bischoff, Thomas, Vargo, Margaret, Fettis, Lu, Wang, Yu, Tian, Adrian, Hobson, Ying, Jia, Jason, Oh, Christopher, Marvin, Theresa, Dunstan   +12 more
core   +2 more sources

Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system

Journal for ImmunoTherapy of Cancer
Background A bidirectional promoter-driven chimeric antigen receptor (CAR) cassette provides the simultaneous expression of two CARs, which significantly enhances dual antigen-targeted CAR T-cell therapy.Methods We developed a second-generation CAR ...
Supannikar Tawinwung, Nattiya Hirankarn, Asmita Khaniya, S M Ali Hossieni Rad, Josh Halpin, Alexander McLellan, Koramit Suppipat   +6 more
doaj   +1 more source

A synthetic notch (synNotch) system linking intratumoral immune-cancer cell communication to a synthetic blood biomarker assay

Frontiers in Pharmacology, 2023
Introduction: Cellular immunotherapy has greatly improved cancer treatment in recent years. For instance, chimeric antigen receptor (CAR) T cell therapy has been proven highly effective in treating hematological malignancies, and many CAR cell designs ...
YangHao Fu, TianDuo Wang, John A. Ronald, John A. Ronald   +3 more
doaj   +1 more source

CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury

Annals of the Rheumatic Diseases
Objectives Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN).
D. Lodka, Maria Zschummel, M. Bunse, A. Rousselle, Janis Sonnemann, R. Kettritz, U. Höpken, A. Schreiber   +7 more
semanticscholar   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Increased NFAT activity with dual CAR stimulation in CD19xCD22 CAR T-cells is associated with decreased exhaustion and improved survival

Journal for ImmunoTherapy of Cancer
Background Chimeric antigen receptor (CAR) T-cell therapy is effective in treating B-cell malignancies, however relapse due to lack of CAR persistence and antigen-modulated escape remains common. Multiple strategies to simultaneously target CD19 and CD22
Terry J Fry, Amanda J Novak, Alexander W Rankin, Catherine Pham-Danis, Etienne Danis, M Eric Kohler   +5 more
doaj   +1 more source

Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function

Blood Advances, 2023
Abstract Therapy with CD19-directed chimeric antigen receptor (CAR) T cells has transformed the treatment of advanced B-cell malignancies. However, loss of or low antigen expression can enable tumor escape and limit the duration of responses achieved with CAR T-cell therapy. Engineering bispecific CAR T cells that target 2 tumor antigens
Isabel Leung, Megan L. Templeton, Yun Lo, Anusha Rajan, Sylvia M. Stull, Sarah M. Garrison, Alexander I. Salter, Kimberly S. Smythe, Colin E. Correnti, Shivani Srivastava, Cecilia C. S. Yeung, Stanley R. Riddell   +11 more
openaire   +2 more sources