Results 161 to 170 of about 58,626 (275)

Excitatory neurons and astrocytes‐specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single‐cell spatial transcriptomics

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang, Qihang Zou, Yingying Liu, Yinchao Li, Yubao Fang, Tiancai Huang, Jiabin Yu, Lisen Sui, Dezhi Cao, Liemin Zhou   +9 more
wiley   +1 more source

Decoding Leukemic Stem Cells in AML: From Identification to Targeted Eradication. [PDF]

Diseases
Apostolidou E, Georgoulis V, Leonardos D, Benetatos L, Kapsali E, Hatzimichael E.   +5 more
europepmc   +1 more source

TGFβ‐Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia

Molecular Carcinogenesis, Volume 65, Issue 5, Page 556-564, May 2026.
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Akash Maity, Rohit Kumar, Madhavi Dutta, Ansit Mishra, Jitendra Gawde, Jagruti Patil, Darshana Kadam, Sumeet Mirgh, Anant Gokarn, Hasmukh Jain, Lingaraj Nayak, Bhausaheb Bagal, Sachin Punatar, Manju Sengar, Navin Khattry, P. G. Subramanian, Prashant Tembhare, Syed K. Hasan   +17 more
wiley   +1 more source

Endothelial progenitor cell numbers vary in newborns and adults; anti-gm-CSFα (CD116) antibody as a novel marker for EPC enumeration. [PDF]

Innate Immun
Simsek S, Karaca C, Koker N, Öztürk A, Koker MY.   +4 more
europepmc   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Comparison of CD34+ cell enumeration between flow cytometric analysis and ADAMII-CD34 image-based fluorescence cell counter. [PDF]

PLoS One
Thedsawad A, Boonmoh S, Taka O, Owattanapanich W.   +3 more
europepmc   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients – PART 1: Risk Factors, Clinical Impact and Immune Response

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan, Emily Blyth, Gaurav Sutrave, Michelle K. Yong, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Lauren Stern   +7 more
wiley   +1 more source

A multimodal atlas for immunotherapeutic targeting of AML surface heterogeneity. [PDF]

iScience
Ung M, Etchin J, Halfond A, DiFazio J, Keschner Y, Pyclik A, Campbell A, Wang R, Silva M, Gjeci B, Montalbano A, Williams R, Mundelboim G, Arruda A, Minden M, Scherer J, Chakraborty T, Ge HG, Lydeard JR.   +18 more
europepmc   +1 more source

Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X‐Inactivation Features

Aging Cell, Volume 25, Issue 5, May 2026.
Loss of chromosome Y in male leukocytes exhibits cell type‐specific effects on immune cell phenotypes and transcriptional profiles along differentiation trajectories. LOY is associated with profibrotic monocyte signatures and aberrant X‐inactivation gene expression, highlighting links to immune dysfunction and age‐related diseases in men.
Ahmed Dawoud, Luke Green, Owen Rackham
wiley   +1 more source