Results 141 to 150 of about 39,027 (253)

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

A multimodal atlas for immunotherapeutic targeting of AML surface heterogeneity. [PDF]

iScience
Ung M, Etchin J, Halfond A, DiFazio J, Keschner Y, Pyclik A, Campbell A, Wang R, Silva M, Gjeci B, Montalbano A, Williams R, Mundelboim G, Arruda A, Minden M, Scherer J, Chakraborty T, Ge HG, Lydeard JR.   +18 more
europepmc   +1 more source

Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Xiaohan Tan, Junlong Hu, Junhui Li, Zhuangying Chen, Xin Shi, Jie Liu, Mingyue Liu, Weiping Hu   +7 more
wiley   +1 more source

Blood cell-derived transplants at 40. [PDF]

Bone Marrow Transplant
Ho AD, Dreger P, Juttner C, Gale RP.
europepmc   +1 more source

Alterations of circulating innate lymphoid cells in recent‐onset type 1 diabetes

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
Circulating innate lymphoid cells (ILC) in patients with recent‐onset type 1 diabetes (T1D) show a chronic activation and a primed phenotype, with overexpression of HLA Class II (ILC1 and ILCP) and dysregulation of costimulatory and migratory mRNA transcripts. Glucose and cytokines (IL‐1β) mediate circulating ILC activation and HLA Class II expression.
Ariadna Roig, David Perna‐Barrull, Eva Aguilera, Sebastián Pérez, Marta Vives‐Pi, Raquel Planas   +5 more
wiley   +1 more source

Comparison of CD34+ cell enumeration between flow cytometric analysis and ADAMII-CD34 image-based fluorescence cell counter. [PDF]

PLoS One
Thedsawad A, Boonmoh S, Taka O, Owattanapanich W.   +3 more
europepmc   +1 more source

Polygonati Rhizoma Attenuates Oxidative Stress‐Induced Senescence in Periodontal Ligament Stem Cells

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Network pharmacology identified the potential targets and pathways of Polygonati Rhizoma (PR) against aging‐related periodontitis through PPI, GO/KEGG enrichment, and molecular docking. Experimental validation in a D‐galactose‐induced senescence model of periodontal ligament stem cells showed that PR‐medicated serum attenuated cellular senescence and ...
Xinran Feng, Ying An, Fanfan Hou, Qian Guo, Shanshan Cai, Hongbin Xu, Youfu He   +6 more
wiley   +1 more source

Generation of iPSC-Derived iNKT Cells with Pro-Hematopoietic Activity. [PDF]

Stem Cell Rev Rep
Kumar A, Ferguson S, D'Souza SS, Bharadwaj NS, Raymond M, Gumperz JE, Slukvin II.   +6 more
europepmc   +1 more source

Cytogenetic and Molecular Analysis of a “Double‐Hit” RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia

Genes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.
ABSTRACT Introduction Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in ...
Rolando García, Jing Xu, Lan Yu, Kalayarasan Srinivasan, Sharon Koorse Germans, Olga Weinberg, Franklin Fuda, Weina Chen, Prasad Koduru   +8 more
wiley   +1 more source

Leukemia Cutis at Initial Diagnosis of Acute Myeloid Leukemia Consistent With Therapy-Related Disease After Lung Cancer Chemotherapy: A Case Report. [PDF]

Case Rep Hematol
Bowen A, DiLoreto N, Bayya M, McDonald R, Isaac D.   +4 more
europepmc   +1 more source