Results 11 to 20 of about 1,140,023 (299)
Hematology, Transfusion and Cell Therapy, 2023 Background: T lymphocytes expressing chimeric antigen receptors (CAR) have been shown to be efficient for tretment of hematologic, but less efficient for solid tumors, due to the great complexity of the tumor microenvironment involving: heterogeneity of ...
IC Ovider +7 more
doaj +1 more source
CD34 antigen: Molecular features and potential clinical applications [PDF]
Stem Cells, 1993 Despite the wide variety of functions exhibited by mature peripheral blood cells, all are derived from a small pool (1-3%) of primitive precursor cells in the bone marrow (BM) that bear a unique surface glycoprotein, CD34. Isolated CD34+ cells are capable of reconstituting all hematopoietic lineages, both in experimental animals and in humans following
D R, Sutherland +2 more
openaire +2 more sources
Blood Advances, 2020 In an attempt to identify novel markers and immunological targets in leukemic stem cells (LSCs) in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), we screened bone marrow (BM) samples from patients with AML (n = 274) or CML (n = 97) and ...
H. Herrmann +18 more
semanticscholar +1 more source
Antigen CD34+ marrow cells engraft lethally irradiated baboons. [PDF]
Journal of Clinical Investigation, 1988 The CD34 antigen is present on 1-4% of human marrow cells including virtually all hematopoietic progenitors detected by in vitro assays. Since the anti-CD34 monoclonal antibody 12-8 reacts with a similar marrow population in baboons, it was possible to test whether this antigen is expressed by stem cells responsible for hematopoietic reconstitution in ...
R J, Berenson +6 more
openaire +2 more sources
Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]
, 2020 Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Bausenwein, Judith +13 more
core +2 more sources
Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]
, 1993 Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL +3 more
core +1 more source
Comparison of Microvessel Density Using Nestin and CD34 in Colorectal Cancer
Anticancer Research, 2018 Background/Aim: The aim of the present study was to compare the prognostic value of nestin-positive microvessel density (nestin+ MVD) to the CD34-positive (CD34+) MVD in patients with colorectal cancer.
M. Chabowski +5 more
semanticscholar +1 more source
Journal of Experimental Medicine, 1989 We determined whether human marrow cells that directly form colonies in vitro could be distinguished from cells that generate or become CFC only after LTMC in the presence of irradiated marrow stromal cells.
R. Andrews, J. Singer, I. Bernstein
semanticscholar +1 more source
Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]
, 2008 Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H. +10 more
core +1 more source
Journal of Experimental Medicine, 1990 CD34+ human marrow cells not expressing T cell-, B cell-, and myeloid cell-associated antigens (TBM-) were cloned by two-color cell sorting into culture wells containing irradiated marrow stromal cells.
R. Andrews, J. Singer, I. Bernstein
semanticscholar +1 more source