Results 11 to 20 of about 8,885 (125)

Tissue-Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts. [PDF]

Am J Hematol
ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Valent P, Wojta J, Kovanen PT, Hermine O, Fend F, Sotlar K, Greinix H, Geissler K, Hartmann K, Schwaab J, Herling M, Boccuni L, Kazianka L, John MV, Sperr WR, Zierfuss C, Tzankov A, Sillaber C, Minkov M, Hoermann G, Collin M, Horny HP, Haferlach T, Sibilia M, Haroche J, La Rosée P, Orfao A, Arock M.   +27 more
europepmc   +2 more sources

Leukocyte Ig-Like Receptors – a model for MHC class I disease associations [PDF]

, 2016
MHC class I (MHC-I) polymorphisms are associated with the outcome of some viral infections and autoimmune diseases. MHC-I proteins present antigenic peptides and are recognized by receptors on natural killer cells and cytotoxic T lymphocytes, thus ...
Allen, R, Hudson, LE
core   +2 more sources

In-Vitro Differentiation of Mature Dendritic Cells From Human Blood Monocytes [PDF]

, 1998
Representing the most potent antigen-presenting cells, dendritic cells (DC) can now be generated from human blood monocytes. We recently presented a novel protocol employing GM-CSF, IL-4, and IFN-γ to differentiate monocyte-derived DC in vitro.
Afsaneh Soruri, Dirk Heise, J. Hinrich Peters, Peter Schwartz, Robert Gieseler   +4 more
core   +2 more sources

Markers of mouse macrophage development detected by monoclonal antibodies [PDF]

, 1994
In this review, we present and discuss a selected panel of antibody-defined markers expressed during different stages of mouse macrophage ...
Bruijn, M.F.T.R. (Marella) de, Campbell, P.A. (Priscilla), Ewijk, W. (Willem) van, Leenen, P.J.M. (Pieter), Voerman, J.S. (Jane)   +4 more
core   +1 more source

The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias [PDF]

, 2016
Tefinostat (CHR-2845) is a novel monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor which is cleaved into its active acid by the intracellular esterase human carboxylesterase-1 (hCE-1).
Bone, Elizabeth, Burnett, Alan, Davidson, Alan, Gilmour, Marie, Hills, Robert, Knapper, Steven, Vyas, Pares, Zabkiewicz, Joanna   +7 more
core   +1 more source

Targeting leukemia stem cells in the bone marrow niche [PDF]

, 2018
The bone marrow (BM) niche encompasses multiple cells of mesenchymal and hematopoietic origin and represents a unique microenvironment that is poised to maintain hematopoietic stem cells.
Bertaina, Chen, Emadi, Godwin, Greenberg, Leone, Mohle, Ng, Rettig, Smith, Staudinger, Uy, Vadakekolathu, Vadakekolathu   +13 more
core   +2 more sources

Expression of an anti-CD33 single-chain antibody by Pichia pastoris [PDF]

, 2005
CD33 is a cell surface glycoprotein expressed on cells of myelomonocytic lineage, leukaemic cells, but not haematopoietic stem cells. By virtue of its expression pattern, CD33 has become a popular target for new immunotherapeutic approaches to treat ...
Emberson, Louise M., Trivett, Amanda J., Blower, Philip J., Nicholls, Peter J.   +3 more
core   +1 more source

Sarcoma immunotherapy. [PDF]

, 2011
Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential ...
Gouw, Launce G, Jones, Kevin B, Randall, R Lor, Sharma, Sunil   +3 more
core   +2 more sources

Long-term human hematopoiesis in the SCID-hu mouse. [PDF]

, 1990
Coimplantation of small fragments of human fetal thymus and fetal liver into immunodeficient SCID mice resulted in the formation of a unique structure (Thy/Liv).
Kaneshima, H, McCune, Joseph, Namikawa, R, Weilbaecher, K, Yee, E   +4 more
core  

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source