Immunophenotypic, Genetic, and Clinical Features Associated With RUNX1 Mutation in Acute Leukemias and Chronic Myeloid Neoplasms [PDF]
ABSTRACT Introduction RUNX1 is a commonly mutated transcriptional regulator of hematopoiesis in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Mutated RUNX1 (mRUNX1) may associate with cross‐lineage immunophenotypic aberrancy, presenting potential complications for blast lineage assignment at diagnosis. Methods Clinical and laboratory
Yi Han Xia, Eric McGinnis
wiley +2 more sources
Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis [PDF]
RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias.
Caraffini, Veronica +39 more
core +1 more source
Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Glenda J. Dickson +16 more
core +1 more source
Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells [PDF]
HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).
Seifert, Roland, Jungblut, P. R.
core +1 more source
A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco +69 more
core +1 more source
12-0-Tetradecanoyl phorbol-13-acetate induced differentiation in human lung squamous carcinoma cells. [PDF]
Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes.
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core +1 more source
Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Laurinyecz, Barbara +25 more
core +1 more source
Comparison of schistosoma mansoni soluble cercarial antigens and soluble egg antigens for serodiagnosing schistosome infections [PDF]
A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid – SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories.
Dawson, E. +40 more
core +2 more sources
Immunity to Intracellular Salmonella Depends on Surface-associated Antigens [PDF]
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Rizos Konstantin +50 more
core +2 more sources
Expression of myeloid differentiation antigens on normal and malignant myeloid cells
been characterized that define four surface antigens (MY3, MY4, MY7, and MY8) of human myeloid cells. They were derived from a fusion of the NS-1 plasmacytoma cell line with splenocytes from a mouse immunized with human acute myelomonocytic leukemia ...
L M Nadler +7 more
core +1 more source

