Results 91 to 100 of about 367,534 (310)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Engineered human B cells targeting tumor-associated antigens exhibit antigen presentation and antibody-mediated functions

Frontiers in Immunology
B cell engineering represents a promising therapeutic strategy that recapitulates adaptive immune functions, such as memory retention, antibody secretion and affinity maturation in murine models of viral infection.
Alexander Boucher, Courtney Anderson, Rochelle Hinman, Molly Kindschuh, Jeremy Fung, Tiansu Wang, Isabella Klooster, Elise Kim, Caroline Roth, Michael Vander Oever, Bakhmala Khan, Natalie Zelikson, Yaron Vagima, Huseyin Saribasak, Lisa Santry, Leah Natasha Klapper, Shmuel Hess, Jill Mooney, Débora Rosa Bublik, Haley Laken, Adi Barzel, Philip Borden, Cherylene Plewa, Ana Maria Chadbourne, Devin Bridgen, Alessio D. Nahmad, Alessio D. Nahmad   +26 more
doaj   +1 more source

Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults [PDF]

, 2013
Background: Adults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells.
Alejandro Armenti, Alicia Serjan, AN Akbar, Ana M. De Rissio, CL Day, D Sauce, Daniel Potente, DE Kaufmann, DE Perez-Mazliah, DM Vitelli-Avelar, E Kuschnir, Eric Dumonteil, GA Schmunis, GC Olivera, GL Bertocchi, Gonzalo Tomas, HW Virgin, J Hernández-Ruiz, J Nikolich-Zugich, JA Fiuza, JP Gigley, Laura E. Fichera, LMG Bahia-Oliveira, M Frentsch, M Samudio, María C. Albareda, María G. Alvarez, MC Albareda, MC Albareda, MC Albareda, MG Alvarez, MJ Yellin, Mónica I. Esteva, NS Joshi, PA Barrett, PA Darrah, PM Odorizzi, R Sathler-Avelar, R Viotti, RA Cutrullis, RA Seder, Rick L. Tarleton, RJ Arguello, RL Tarleton, Rodolfo Viotti, S Le Saux, S Sosa-Estani, S Vigano, SA Laucella, SA Laucella, SA Laucella, SM Henson, Susana A. Laucella, WO Dutra   +53 more
core   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Exploration of altered miRNA expression and function in MSC-derived extracellular vesicles in response to hydatid antigen stimulation

Frontiers in Microbiology
BackgroundHydatid disease is caused by Echinococcus parasites and can affect various tissues and organs in the body. The disease is characterized by the presence of hydatid cysts, which contain specific antigens that interact with the host’s immune ...
Xin Wang, Wubulikasimu Mijiti, Qiyu Jia, Zhifei Yi, Junchao Ma, Ziyu Zhou, Zengru Xie, Zengru Xie, Zengru Xie   +8 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The use of antigens derived from Bacillus thuringiensis bacteria for further differentiation

Heliyon
This study is devoted to studying Bacillus thuringiensis antigens and their insecticide activity as critical features in bacterial differentiation.
Ekaterina Savelyeva, Aleksei Avdeenko
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source