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Senescent Cell Antigen: A Terminal Differentiation Antigen
Pathology and Immunopathology Research, 1985Investigations into mechanisms by which macrophages distinguish mature from senescent self cells revealed that a approximately 62,000 Mr glycoprotein, the senescent cell antigen, a terminal differentiation antigen, appears on the surface of senescent and damaged cells. It is recognized by the antigen-binding Fab region of a specific IgG autoantibody in
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Carbohydrate differentiation antigens
Trends in Biochemical Sciences, 1981Abstract Studies with monoclonal antibodies specific for defined carbohydrate sequences have shown that some of the changing antigenicities in the glycoproteins and glycolipids of cells, during successive developmental stages, may be brought about by sequential addition or deletion of monosaccharide residues.
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Human Mononuclear Phagocytes Differentiation Antigens
1982Cell surface antigenic analysis using 10 different monoclonal antibodies indicates the following. (a) The membrane antigenic phenotype of various members of the mononuclear phagocyte lineage is characterized by the co-expression of multiple but distinct antigenic determinants.
A, Dimitriu-Bona +2 more
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Differentiation Antigens and Macrophage Heterogeneity
1982The macrophage provides a favorable system to study differentiation in eukaryotic cells. Multipotential hemopoietic precursors proliferate and differentiate in response to ill-defined signals and are then widely distributed via the blood stream as mature members of the “Mononuclear Phagocyte System”.
S, Gordon, S, Hirsch
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Membrane antigen expression during hemopoietic differentiation
Critical Reviews in Oncology/Hematology, 1986The pattern of certain groups of antigens expressed on the surface of hemopoietic cells changes either during the course of differentiation from pluripotent stem cells to mature functional cells or as a function of the proliferative state of the cells. A map of these changes is emerging and is providing valuable information for selecting and purifying ...
C.A. Sieff, John W. Adamson
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Differential antigen preservation during tissue autolysis
Human Pathology, 1991Immediate fixation or snap freezing of tissue is ordinarily done to maximize antigen preservation for immunocytochemistry; however, delay in tissue allocation or spontaneous lymph node infarction can render tissue suboptimal for immunostaining. To test the effects of tissue autolysis/necrosis on the preservation of various lymphoid, epithelial, and ...
R J, Pelstring +4 more
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DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS
Annual Review of Immunology, 1997▪ Abstract Studies performed during the past several years make plain that ligand occupancy of antigen receptors need not necessarily provoke identical responses in all instances. For example, ligation of antigen receptors may stimulate a proliferative response, induce a state of unresponsiveness to subsequent stimulation (anergy), or induce apoptosis.
J, Alberola-Ila +3 more
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Serological identification of thymocyte differentiation antigens
Human Immunology, 1988We have examined subfractions of human thymocytes for the expression of novel differentiation antigens. Non-HLA alloantisera procured from multiparous women served as antibody probes. Thymocytes from five individuals were sequentially separated by discontinuous Percoll density gradient centrifugation and a peanut agglutinin (PNA) panning technique ...
S, Park +5 more
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Antigen-Initiated B Lymphocyte Differentiation
The Journal of Immunology, 1975Abstract Distinct sub-populations of B lymphocytes may be fractionated by passage through glass-bead columns, due to a temperature-independent adherence of certain cells. The relative adherence properties of AFC-progenitors from spleens of primed or unprimed CBA mice were compared with an adoptive immune assay employing as antigen the ...
Robert A Schlegel, Ken Shortman
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Antigen Density on Differentiating Erythroid Cells
Nature New Biology, 1972THERE is a conflict of evidence about the development of erythrocyte antigens in the course of cell differentiation and maturation. Some reports suggest that antigens characteristic of mature erythrocytes can be demonstrated even on immature precursor cells1,2, but others3,4 suggest that red cell development is accompanied by significant changes of ...
Minio, F, Howe, C, Hsu, K, Rifkind, R
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