Results 91 to 100 of about 214,753 (272)

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss (VML) due to trauma or surgery, often leads to physical impairments. Traditional treatments rely on autologous flaps, limited by muscle availability often leading to donor site morbidity. This study presents multimodal bioprinting as an innovative approach for fabricating vascularized muscle flaps with 3D‐printed macrovessels ...
Eliana O. Fischer, Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Asaf Silverstein, Maya Yaakov, Orit Bar‐Am, Lior Debbi, Shulamit Levenberg   +8 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

Pathogens
The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated not only with the development of acute disease but also with long-term symptoms or post-acute sequelae of SARS-CoV-2 (PASC).
Lorenzo Lupi, Adriana Vitiello, Cristina Parolin, Arianna Calistri, Alfredo Garzino-Demo   +4 more
doaj   +1 more source

A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants.

PLoS ONE, 2020
The hepatitis B virus (HBV) envelope is composed of a lipid bilayer and three glycoproteins, referred to as the large (L), middle (M), and small (S) hepatitis B virus surface antigens (HBsAg). S protein constitutes the major portion of the viral envelope
Gi Uk Jeong, Byung-Yoon Ahn, Jaesung Jung, Hyunjin Kim, Tae-Hee Kim, Woohyun Kim, Ara Lee, Kyuhyun Lee, Jung-Hwan Kim   +8 more
doaj   +1 more source

Explaining the geographic origins of seasonal influenza A (H3N2) [PDF]

arXiv, 2016
Most antigenically novel and evolutionarily successful strains of seasonal influenza A (H3N2) originate in East, South, and Southeast Asia. To understand this pattern, we simulated the ecological and evolutionary dynamics of influenza in a host metapopulation representing the temperate north, tropics, and temperate south.
arxiv  

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, EarlyView.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source

Viral Antigens in Human Epidermal Tumors

Journal of Investigative Dermatology, 1963
Only two of the epidermal tumors of man unquestionably result from a virus infection- warts and molluscum contagiosum. Neither of these contains a potent antigen. Antibodies to warts, for instance, have not been demonstrated, and until recently the situation for molluscum contagiosum remained controversial; most workers had failed to find humoral ...
William L. Epstein, Hedwig Krasnobrod, Irene P. Senecal, Alan M. Massing   +3 more
openaire   +2 more sources

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections [PDF]

arXiv, 2015
The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, forming an evolutionary arms race.
arxiv  

Personalized workflow to identify optimal T-cell epitopes for peptide-based vaccines against COVID-19 [PDF]

arXiv, 2020
Traditional vaccines against viruses are designed to target their surface proteins, i.e., antigens, which can trigger the immune system to produce specific antibodies to capture and neutralize the viruses. However, viruses often evolve quickly, and their antigens are prone to mutations to avoid recognition by the antibodies (antigenic drift).
arxiv