Results 81 to 90 of about 270,928 (312)
Surface-displayed viral antigens on Salmonella carrier vaccine
, 2000 We have developed a recombinant live oral vaccine using the ice- nucleation protein (Inp) from Pseudomonas syringae to display viral antigens on the surface of Salmonella spp.
Chul Joong Kim +7 more
core +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Concentration of Complement Fixing Viral Antigens.
Experimental Biology and Medicine, 1966 SummaryComplement fixing antigens produced in cell culture by a variety of viruses were concentrated by slow speed sedimentation of undisrupted virus infected cells and removal of the supernatant medium. In most cases, concentration of virus infectivity was demonstrated as well.
K, Schell, R J, Huebner, H C, Turner
openaire +2 more sources
Temporal regulation of murine cytomegalovirus transcription and mapping of viral RNA synthesized at immediate early times after infection [PDF]
, 1984 The replication of murine cytomegalovirus strain Smith in murine embryonic fibroblasts was investigated at immediate early, early, and late times after infection.
Koszinowski, Ulrich H. +2 more
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Outer membrane vesicles (OMVs) and their therapeutic potential as anti-infectious agents
Nano TrendsOuter membrane vesicles (OMVs) derived from Gram-negative bacteria have emerged as promising therapeutic agents for combating infectious diseases. These small, spherical structures carry diverse cargo molecules, including virulence factors, antigens, and
Mariana Ottaiano Gonçalves +4 more
doaj +1 more source
Mechanism of viral antigen processing and presentation.
Uirusu, 1993 Zinkernagel & Doherty (1974)によるキラーT細胞のウイルス感染標的細胞認識におけるMHC拘束性の発見から20年足らずで, この問題がウイルス抗原プロセッシングに関するMHC拘束性を反映したものであることが明らかになってきた。この経過も興味あるもので, この間にクラスI及びクラスII経路の違いも明らかになってきた。従来, 熱不活化インフルエンザウイルスを用いて抗原提示機構の独自の研究を続けてきた我々の研究室では, 国産のMHC表現欠損細胞をいただいて, ウイルス抗原提示機構の研究の新しい局面を切り開いている。インフルエンザウイルス-L929細胞 (H-2k) の系で研究を続けてきた経過から, 変異細胞はH-2kマウス由来のものである必要があった。C3Hマウス由来の ...
Hosaka, Yasuhiro, Kuroda, Kazumichi
openaire +3 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Displaying and delivering viral membrane antigens via WW domain–activated extracellular vesicles
, 2023 Membrane proteins expressed on the surface of enveloped viruses are conformational antigens readily recognized by B cells of the immune system. An effective vaccine would require the synthesis and delivery of these native conformational antigens in lipid
Wiggins, Joshua +7 more
core +4 more sources