Results 81 to 90 of about 258,807 (267)
Mechanism of viral antigen processing and presentation.
Uirusu, 1993 Zinkernagel & Doherty (1974)によるキラーT細胞のウイルス感染標的細胞認識におけるMHC拘束性の発見から20年足らずで, この問題がウイルス抗原プロセッシングに関するMHC拘束性を反映したものであることが明らかになってきた。この経過も興味あるもので, この間にクラスI及びクラスII経路の違いも明らかになってきた。従来, 熱不活化インフルエンザウイルスを用いて抗原提示機構の独自の研究を続けてきた我々の研究室では, 国産のMHC表現欠損細胞をいただいて, ウイルス抗原提示機構の研究の新しい局面を切り開いている。インフルエンザウイルス-L929細胞 (H-2k) の系で研究を続けてきた経過から, 変異細胞はH-2kマウス由来のものである必要があった。C3Hマウス由来の ...
Hosaka, Yasuhiro, Kuroda, Kazumichi
openaire +3 more sources
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
Ode to Oseltamivir and Amantadine?
Canadian Journal of Infectious Diseases and Medical Microbiology, 2006 Influenza A and B viruses are the two major types of influenza viruses that cause human epidemic disease. Influenza A viruses are further categorized into subtypes based on two surface antigens: hemagglutinin (H) and neuraminidase (N).
JM Conly, BL Johnston
doaj +1 more source
Frontiers in Immunology, 2014 Effective viral clearance requires the induction of virus-specific CD8+ cytotoxic T lymphocytes (CTL). Since dendritic cells (DC) have a central role in initiating and shaping virus-specific CTL responses, it is important to understand how DC initiate ...
Nadine eVan Montfoort +2 more
doaj +1 more source
Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery
Advanced Functional Materials, EarlyView.This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar +4 more
wiley +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Advanced Functional Materials, EarlyView.Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
A tumor-binding antibody with cross-reactivity to viral antigens
Cancer Immunology, ImmunotherapyBackground We previously identified in non-small cell lung cancer (NSCLC) patients an autoantibody to complement factor H (CFH) that is associated with non-metastatic disease and longer time to progression in patients with stage I disease.
Michael J. Campa +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco +7 more
wiley +1 more source
Portable Molecularly Imprinted Polymer Sensor for Rapid Swab‐Based Detection of Norovirus
Advanced Healthcare Materials, EarlyView.This work reports a rapid, portable smartphone‐based sensor capable of detecting four norovirus genotypes from swab samples within 15 min. Sensor selectivity was validated through evaluation against four common live viruses. The swab‐based sampling process enabled simple sample preparation combined with the compact detection system, supporting use of ...
Amy Dann +13 more
wiley +1 more source