Results 191 to 200 of about 214,753 (272)

Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Advanced Science, EarlyView.
Immunomodulatory metal‐phenolic microcapsules (mMPMs) is developed in this study that leverages dopamine‐modified hyaluronic acid and FeIII assemble on mannose‐glycated bovine serum albumin microbubbles. mMPMs effectively promote macrophage internalization and M1 polarization, enhancing pro‐inflammatory responses.
Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge   +9 more
wiley   +1 more source

Unveiling kaposi sarcoma viral antigens

Oncotarget, 2017
Richard F. Ambinder, Jaeyeun Lee, John G. Kosowicz   +2 more
openaire   +2 more sources

Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages. [PDF]

Sci Adv
Page CK, Shepard JD, Ray SD, Ferguson JA, Rodriguez AJ, Han J, Jacob JC, Rowe-Haas DK, Akinpelu JY, Friedman LM, Hertz T, Ward AB, Tompkins SM.   +12 more
europepmc   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Inflammatory and neuropathological responses to <i>Vesiculovirus carajas</i> encephalitis in adult mice: variability, tolerance and resistance. [PDF]

Front Cell Infect Microbiol
Cavalcante MSB, Santos DS, Araújo LM, Freitas PL, Silva CAM, Carvalho KGB, Araújo MTF, da Silva EVP, Rodrigues de Farias APD, Guerreiro Diniz D, Picanço Diniz CW, Diniz JAP.   +11 more
europepmc   +1 more source

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Advanced Science, EarlyView.
Low reproducibility and inefficient gene transfer hamper clinical manufacturing of chimeric antigen receptor regulatory T cells (CAR Tregs). Nanoneedle mediated electroporation generates primary human CAR Tregs under good manufacturing practice conditions with superior efficiency compared to viral transduction.
Ningjia Sun, Cong Wang, William Edwards, Yikai Wang, Xiangrong L. Lu, Chenlei Gu, Samuel McLennan, Panicos Shangaris, Peng Qi, Daniela Mastronicola, Cristiano Scottà, Giovanna Lombardi, Ciro Chiappini   +12 more
wiley   +1 more source

Mucosal immunotherapy targeting APC in lung disease. [PDF]

J Inflamm (Lond)
Liu Y, Chen Z, Cheng H, Zheng R, Huang W.   +4 more
europepmc   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source

COVID-19-Associated Cold Agglutinin Syndrome and Hemophagocytosis in a Patient with Monoclonal Gammopathy of Undetermined Significance. [PDF]

Mediterr J Hematol Infect Dis
Yu Y, Yang K.
europepmc   +1 more source

Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury

Advanced Science, EarlyView.
A biomimetic MOF nanocarrier for macrophage‐targeting delivery of both mitochondria and anti‐miR‐127 is designed with an aim to revitalize macrophages and remold the inflammatory microenvironment for treating acute lung injury. By leveraging the macrophages‐targeting property and pH‐responsiveness, ZIF‐8 nanocarriers facilitated efficient delivery of ...
Xin Shou, Changjiang Chen, Hangjie Ying, Zhiyun Liu, Lingyao Zeng, Qiujie Li, Lanjie Lei, Bingyong Mao, Wei Zhang, Shumao Cui, Liyun Shi   +10 more
wiley   +1 more source